Cheapest GLP-1 over 12 months
The cheapest GLP-1 across a full year is usually compounded semaglutide, because introductory rates expire and annual prepay plans lock you in.
TLDR. The cheapest GLP-1 over a full year is not always the one with the cheapest first month. Introductory rates expire, annual prepay plans lower the monthly price while locking you in, and compounded semaglutide usually carries the lowest twelve-month total. The table below ranks every program on our chart by what a year actually costs, and the prices are checked every Monday.
21 programs with a verified price, ranked by what a full year costs. The first-year total counts the introductory rate for as long as it runs, then the maintenance price. Checked Aug 17, 2026.
| Program | Supply | First month | Per month after | First year total |
|---|---|---|---|---|
| Strut Health | Compounded | $149 | $149 | $1,788 |
| Shed | Either | $159 | $159 | $1,908 |
| Found | Either | $169 | $169 | $2,028 |
| Mochi Health | Compounded | $138 | $178 | $2,096 |
| Ivim Health | Either | $175 | $175 | $2,100 |
| Calibrate (plan copay) | Branded | $224 | $224 | $2,688 |
| Noom Med | Either | $129 | $249 | $2,868 |
| WeightWatchers Clinic | Branded | $25 for 3 months | $373 | $3,432 |
| Amazon Pharmacy | Branded | $299 | $299 | $3,588 |
| Knownwell | Branded | $299 | $299 | $3,588 |
| Medvi | Compounded | $299 | $299 | $3,588 |
| Sam's Club Member Health | Branded | $299 | $299 | $3,588 |
| Hone Health | Compounded | $315 | $315 | $3,780 |
| CVS MinuteClinic | Branded | $328 | $328 | $3,936 |
| Walgreens Weight Management | Branded | $348 | $348 | $4,176 |
| Ro Body | Branded | $188 | $373 | $4,291 |
| GoodRx for Weight Loss | Branded | $388 | $388 | $4,656 |
| Sesame Care | Either | $398 | $398 | $4,776 |
| Costco / Success by Sesame | Branded | $408 | $408 | $4,896 |
| Hims & Hers | Branded | $188 | $448 | $5,116 |
| LifeMD | Branded | $188 | $448 | $5,116 |
Over a full year the range runs from $1,788 at Strut Health to $5,116 at LifeMD. Compare all 21 on the chart.
Why the cheapest month is not the cheapest year
A low first month is a common hook. Some programs charge $25 or $99 to start, then move to a higher maintenance price after a month or two. A program that wins on the first month can sit near the bottom once you total twelve of them. The first-year figure above counts the introductory rate for as long as it runs, then the regular price, so it reflects what you would actually pay.
Annual prepay plans lower the monthly price and lock you in
Several programs cut the monthly price when you pay for twelve months up front. That can produce the lowest number on the chart. The trade is commitment. Most annual plans are non-refundable once the medication ships, so the savings depend on staying on treatment for the full year. If you expect to continue, prepaying saves money. If you might stop, a month-to-month plan costs more each month but lets you leave any time.
Where compounded fits
Compounded semaglutide from a licensed US pharmacy is usually the lowest ongoing price, and it often carries the lowest twelve-month total as well. It is the cheapest legitimate route for most people paying cash. Our compounded pharmacy comparison lists the programs and what each one charges.
How to compare over a year
Compare the first-year total rather than the headline first month. The programs at the top of the table are the cheapest across a full year at today's verified prices. For the state-by-state view, see cheapest GLP-1 by state, and the full ranked chart on our homepage.
What is the cheapest GLP-1 over a year?
The table above ranks every program on our chart by first-year total. Compounded semaglutide is usually the lowest. Prices are checked every Monday, so the order can change when a program reprices.
Are annual GLP-1 plans cheaper?
Paying for a year up front often lowers the monthly price, but the plan is usually non-refundable once the medication ships. It saves money only if you stay on treatment for the full year.
Does the cheapest first month mean the cheapest year?
No. Introductory rates expire after a month or two, and the first-year total is the number to compare.
See the full picture on our comparison chart, and the month-by-month maintenance math in our guide to GLP-1 maintenance dose costs.
This week's best deals
Compare these programs
