Best of

Best weight loss programs by use case.

31 picks across cash-pay, insurance, speed, lock-in, budget and clinical depth. Scored on the criteria that actually matter for each use case.

These lists are not one ranking. The best GLP-1 program depends entirely on what you are optimizing for, so we built a separate shortlist for each situation and scored each one on the criteria that matter for that situation, not on a generic average.

If you only care about price, start with the cash-pay and cheapest shortlists. The floor for the actual medication is about $178 a month for compounded semaglutide, and the gap between the cheapest program and the most expensive one is wider than most people expect for the same drug class.

If you have commercial insurance, the insurance shortlist surfaces programs most patients never find: the ones that will run a prior authorization for you instead of pushing you straight to cash. If you want to avoid a contract, the no-lock-in list filters for month-to-month billing. If you want to start fast, the speed list ranks programs by how quickly you can get a first prescription.

Every pick is scored, dated, and checked, and we take no payment for placement. Pick the list that matches your situation below, or find your program in four quick questions if you would rather be pointed straight to the one that fits.

For picks based on a specific medical condition (T2D, CKD, sleep apnea, PCOS, MASH), see GLP-1 by condition. To compare any two programs side by side, use the GLP-1 program comparison chart.

Before using any ranking, it is worth knowing how rankings in this category work. Our editorial on who actually writes GLP-1 rankings explains why most page-one lists are written by someone with a financial stake in the outcome, and the four questions any independent list should answer.

Common questions

Which GLP-1 program is best?

There is no single best program. It depends on whether you are paying cash, using insurance, or prioritizing speed or no lock-in. We publish a separate scored shortlist for each situation rather than one generic ranking.

What is the cheapest GLP-1 program?

The cheapest cash route to the medication is compounded semaglutide at about $178 a month, billed month-to-month with no lock-in. The cheapest-programs shortlist ranks every program by all-in maintenance price.

Which GLP-1 program is best if I have insurance?

The programs worth starting with are the ones that will file a prior authorization for you rather than defaulting you straight to cash. The insurance shortlist ranks them, and we publish prior-authorization templates by payer.

Why you can trust GLP ChartSame scoring framework applied to every program. No paid placements. We never remove unfavorable information at an advertiser's request. Pricing is pulled from each program's public-facing page every Monday.