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The best truly month-to-month GLP-1 program with no annual commitment of 2026

Many GLP-1 programs sell a 'month-to-month' price that's actually a 6 or 12-month commitment with a prepay or non-refundable enrollment fee. Seventeen programs in our chart are genuinely month-to-month. Three of them make the cancel button easy to find.

The short answer

Henry Meds is our top pick for genuine month-to-month with no lock-in. Score 8.0. One price at every dose, $297 a month with no membership fee, online cancel, no prepay or minimum, and no non-refundable enrollment fee. The cleanest month-to-month structure in our chart.

What to know first

The phrase 'month-to-month' is doing a lot of work in GLP-1 telehealth marketing. Several programs advertise month-to-month pricing but charge a non-refundable enrollment fee, require a 3-month or 6-month minimum, or auto-enroll you in an annual prepay at the second renewal. True month-to-month means: no minimum commitment, no prepay, online self-serve cancellation, no penalty on the next cycle. About 10 to 15 percent of new GLP-1 patients discontinue inside the first 30 days due to gastrointestinal side effects. Programs that lock you in for 6 or 12 months ahead of that risk window are betting against your discontinuation rate.

What we considered

  • Self-serve online cancellation (not phone-only)
  • No minimum commitment period
  • No non-refundable upfront fees
  • Cancellation effective at end of current cycle (not at end of multi-month commitment)
  • Upfront about the cancellation flow (no retention-script obstacle course)

Scores are equal-weighted across five dimensions. How we score

Top pick: Henry Meds

Best for cheapest compounded

Henry Meds logo
Henry MedsFlat-priced compounded semaglutide at every dose, plus an under-the-tongue version.
Starts from
$297/moincl. medication
Lock-in
Month-to-month
Score
8
Read reviewCheck price →

Henry Meds charges $297 a month at every dose and the medication is in that price. You cancel online, with no prepay and no minimum term. Sesame Care also cancels month to month, but its $99 plan does not include the drug, which puts the all-in at $398 a month.

Why Henry Meds won this category

Henry's cancellation terms are the cleanest in our chart. You cancel online and it takes effect at the end of the cycle you have already paid for. No phone call, no retention specialist. Sesame Care's $99 plan also cancels month to month, but Sesame does not fill the prescription, so the medication is bought and priced separately.

The pricing is structurally month-to-month, not a marketing label. $297 a month at every dose, with no membership fee. Prepaying six or twelve months lowers the rate, but nothing converts your subscription to an annual commitment. Several programs in our chart require a minimum commitment instead, including WeightWatchers Clinic at 12 months and Calibrate at three; Henry doesn't.

The clinical commitment is not the same as the financial commitment. GLP-1 weight loss works best when sustained for 12+ months. That is not in dispute. But the program's financial structure should not be the lever that forces your clinical commitment. Henry's model is 'stay because it works for you, not because cancellation would cost you 6 months of unused months.'

The compounded medication path is the trade-off. Henry prescribes compounded semaglutide from 503A pharmacies, a pharmacy-made version that is not FDA-approved and is not Wegovy or Ozempic. For patients who specifically want brand, Ro Body prescribes branded Zepbound through LillyDirect. The medication runs $299 a month, with Ro's membership billed on top.

Who this pick isn't for

Henry is not the right pick if you want the lowest month-to-month price. Strut Health is $149 a month with auto-refill and Shed is $199, both month to month. Henry's edge is one price at every dose with no membership and a clean exit, not the lowest number.

Henry is also not the right pick if you have insurance that covers GLP-1 weight loss with prior authorization. An insured copay is set by your plan's formulary tier and usually beats $297 in cash. Knownwell bills your plan for visits. Prior authorization takes 4 to 6 weeks.

And Henry doesn't fit if your reason for wanting month-to-month is that you're not yet committed to GLP-1 at all. If you're shopping for a trial month to see what GLP-1 feels like, you're better off with a free or low-cost initial PCP consult (Sesame Care, your existing PCP, or a basic insurance-billed visit) before paying for a full month of telehealth membership plus medication.

Runner-up: Sesame Care

Sesame Care cancels from your account with no term to serve out, at $99 a month billed monthly. The difference is that Sesame does not dispense, so the drug is bought and priced separately.

Best for self-directed buyers

Sesame Care logo
Sesame CareSesame Care's Success by Sesame subscription is billed every month at $99 and cancels from your account, with no term to serve out. Only the cheaper $79, $69 and $59 rates ask for a 3, 6 or 12-month commitment. Sesame does not dispense, so the medication is bought and priced separately at whatever pharmacy you pick.
Starts from
$398/mo+ med separate
Lock-in
Month-to-month
Score
7.8
Read reviewCheck price →

Top 3 compared

ProgramScoreStarts fromLock-inTime to Rx
Henry Meds8$297/moMonth-to-month2 days
Sesame Care7.8$398/moMonth-to-month1 day

Other strong picks

Best for self-directed buyers

Sesame Care logo
Sesame CareSesame Care's Success by Sesame subscription is billed every month at $99 and cancels from your account, with no term to serve out. Only the cheaper $79, $69 and $59 rates ask for a 3, 6 or 12-month commitment. Sesame does not dispense, so the medication is bought and priced separately at whatever pharmacy you pick.
Starts from
$398/mo+ med separate
Lock-in
Month-to-month
Score
7.8
Read reviewCheck price →

Frequently asked questions

What's the difference between 'no minimum commitment' and 'month-to-month'?
Sometimes nothing, sometimes a lot. Some programs say 'no minimum commitment' but require you to prepay 3 months upfront on a non-refundable basis. The technically-monthly billing is irrelevant if the prepay is forfeit. True month-to-month means you pay one month at a time, no prepay, and cancellation is effective at the end of the current paid month.
What if I cancel mid-month?
At Henry, cancellation is effective at the end of the current billing cycle. You don't get a partial refund for the remaining days; you get to finish out the month you paid for. If you cancel on day 28 of a 30-day cycle, you have 2 more days of access. If you cancel on day 3, you have 27 more days. The medication you already received doesn't get clawed back.
Can I pause without canceling?
Henry doesn't offer a formal pause. The clean path is to cancel, take a break (which costs you nothing), and re-enroll when you're ready. Some patients prefer this to a pause feature because pause features often have hidden minimums or convert to lock-in after a certain period. Re-enrollment is the same intake as a new patient.
What about the cancellation flow itself?
Henry's cancellation is online from your account. No phone call required. No retention specialist. No 20-minute retention script. Programs that require phone-only cancellation (or where 'online cancel' redirects to a chatbot that won't actually cancel) are the ones to avoid; we score that as a cancellation-friction issue, not a true month-to-month structure.
Will canceling affect my medical record?
Cancellation closes your account at the program. It doesn't affect medication records held by the pharmacy that filled your prescription. If you cancel and then re-enroll (at the same or different program) the new program can request your prior records via standard medical-records release. There's no 'cancellation penalty' that affects your medical history.
Do I have to give a reason for canceling?
Henry asks but doesn't require. The cancellation goes through whether you skip the survey or answer it. Programs that won't let you cancel without a reason form are pushing the friction; that's the kind of behavior we score against in cancellation dimension.
What about programs that auto-renew into annual prepay?
Some programs convert monthly subscriptions to annual prepay at the second renewal as a 'loyalty discount.' If you don't opt out before the conversion date, you're locked in for 12 months. Henry doesn't do this. Read the renewal terms on any program before your second renewal hits; the conversion clause is often buried in the terms page.

Sources

  • GLP-1 cost guideCash, compounded, insurance, and Medicare. What each path costs per month and per year.
  • How we scoreFive dimensions, ten points each. The same framework applied to every program.
  • Monthly rankingsEvery program scored and ranked this month, updated weekly.
  • Full chartEvery program ranked in one view.
  • Learn the categoryLong-form explainers on pricing, regulation, contracts.
John Samaras, editor of GLP Chart
Written and edited by John SamarasAbout this siteContact
Why you can trust GLP Chart. Same scoring framework applied to every program. No paid placements. We never remove unfavorable information at an advertiser's request. Pricing is pulled from each program's public-facing page every Monday.