Do GLP-1 supplements work?
No. Nothing sold as a GLP-1 supplement is a GLP-1 drug. In the studies, the ingredients moved weight by a few pounds or not at all. In the drug trials, people lost 14 to 21 percent of their body weight on average.
These supplements cost $15 to $90 a month. A prescription costs $149 a month, with auto-refill, at Strut Health, for compounded semaglutide, a pharmacy-made version that is not FDA-approved and is not Wegovy, Ozempic, Zepbound or Mounjaro.
Two cash programs to check.
No insurance needed.
- Strut Health$149 a month, with auto-refillcompounded semaglutideCheck price →Semaglutide shot or lozenge, then a health questionnaire
- Shed$199 a monthcompounded semaglutideCheck price →Every medication is listed with a starting price
The products, one by one
Each price is a month at the label dose, read from the maker's own page or its archived product data in the week of September 28, 2026.
| Product | What is in it | What the studies found | A month costs | Lawsuits |
|---|---|---|---|---|
| BerberineSold as “nature’s Ozempic” | Berberine, a compound from plants such as barberry. A common label says 500 mg twice a day. | A 2025 review pooled 23 trials: 0.88 kg (about 2 pounds) more weight lost than the comparison group. The authors flag a lack of blinding and randomization. We found no published study in people showing it raises GLP-1. | $25 to $50 at two capsules a day (NOW Foods $25, Thorne $44, Nature Made $50). | None found |
| Lemme GLP-1 DailyLemme. Now sold as Lemme Reset GLP-1 Production Support | Lemon extract (Eriomin) 200 mg, saffron extract (Supresa) 176.5 mg and blood orange extract (Morosil) 400 mg, in two capsules a day. | Lemme’s page says the product “does not contain GLP-1 or synthetic GLP-1 and is not a GLP-1 agonist drug,” and that the studies behind it are of the ingredients, not the finished formula. The lemon extract raised fasting GLP-1 by about 15 percent and did not change weight (103 people, 12 weeks). On the orange extract, people lost 4.2 percent of body weight against 2.2 percent on placebo, with diet and exercise (180 people, 6 months). The ingredient makers paid for both studies. | $80 a bottle, or $64 on a four-week subscription. A bottle lasts 30 days (lemmelive.com, as archived September 13, 2026). |
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| Pendulum GLP-1 ProbioticPendulum Therapeutics | Three gut bacteria (Akkermansia, Clostridium butyricum, Bifidobacterium infantis) and 211 mg of chicory inulin, one capsule a day. | No published study of this product. The company’s trial of a related five-strain formula (76 adults with type 2 diabetes, 12 weeks) found “no observed effect on body weight” and reported no GLP-1 result. Its page says the product “does not contain GLP-1 and is not a GLP-1 agonist drug” and is “Not intended for weight loss.” | $89, or $64 a month as a member (pendulumlife.com). | None found |
| Supergut GLP-1 BoosterSupergut. Now sold as GLP-1 Daily Support | A fiber powder: corn fiber, green banana and potato resistant starch, and oat beta glucan. 6 grams of fiber a scoop; the label does not give each amount. | No published study of this powder. The maker’s registered trial tested its meal shake. In a separate trial, 40 grams a day of resistant starch, almost seven times the fiber in a scoop, led to 2.8 kg (about 6 pounds) of weight loss over 8 weeks (37 people). | $45 at one scoop a day, $90 at the two scoops the page also suggests. $60 for 40 scoops (supergut.com). |
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| ColonBroom GLP-1 BoosterUAB Gut Health, a Lithuanian company | Berberine, zinc, quercetin and Japanese knotweed extract, one capsule a day. The maker’s page does not show the amounts. | No published study of this product. For berberine, see the first row. | $69.99, or $49.99 on subscription (colonbroom.com). | None found |
| Codeage GLP-1 Probiotic+Codeage | The same three bacteria as Pendulum’s and 211 mg of chicory inulin, one capsule a day. | No published study of this product. Its page says: “Do not use for weight reduction.” | $24.99 for 30 capsules, or $10 a month in the 90-capsule bottle (codeage.com). | None found |
| Bioma GLP-1 BoosterUAB Bioma Health, a Lithuanian company | Sukre 400 mg, triacetin 200 mg, two probiotic strains, cayenne and Akkermansia, in two capsules a day. | No published study of this product. | $67.99, or $50.39 on a subscription that renews until you cancel (bioma.health). | None found |
| Veracity Metabolism IgniteVeracity Wellness | Lemon verbena and hibiscus extract (Metabolaid) 500 mg, green coffee bean extract 250 mg and magnesium, in two capsules a day. | No published study of this product. | $75, or $67.50 on subscription (veracityhealth.co). |
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| GLP-1 patchesSeveral sellers, often renamed berberine patches | Skin patches with berberine, cinnamon, pomegranate and other extracts. One seller’s patch carries 8.75 mg of berberine. | No published study of any supplement patch in people. A 2026 review of 24 patches on sale found no lab results posted, and its authors note that federal law defines a supplement as something swallowed. | $15 for 30 patches (kindpatches.com). |
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How the weight loss compares
Average weight change in each study, next to the group given a placebo (a dummy pill or shot) where there was one. The drug trials ran 64 to 72 weeks. The supplement studies ran 8 weeks to 6 months. The berberine row is a pooled review.
| What was tested | Study | Weight change |
|---|---|---|
| Wegovy shot (semaglutide 2.4 mg a week) | STEP 1: 1,961 adults, 68 weeks, New England Journal of Medicine, 2021 | 14.9 percent lost, 2.4 percent on placebo |
| Zepbound (tirzepatide 15 mg a week) | SURMOUNT-1: 2,539 adults, 72 weeks, New England Journal of Medicine, 2022 | 20.9 percent lost, 3.1 percent on placebo |
| Wegovy pill (semaglutide 25 mg a day) | OASIS 4: 307 adults, 64 weeks, New England Journal of Medicine, 2025 | 13.6 percent lost, 2.2 percent on placebo |
| Berberine | 23 trials pooled, International Journal of Obesity, 2025 | 0.88 kg (about 2 pounds) more than the comparison group |
| Blood orange extract (Morosil, in Lemme) | 180 adults, 6 months, Nutrients, 2022 | 4.2 percent lost, 2.2 percent on placebo, with diet and exercise |
| Resistant starch, 40 grams a day | 37 adults, 8 weeks, Nature Metabolism, 2024 | 2.8 kg (about 6 pounds) lost |
| Lemon extract (Eriomin, in Lemme) | 103 adults with prediabetes, 12 weeks, Phytotherapy Research, 2019 | No change in weight |
| Pendulum’s five-strain formula | 76 adults with type 2 diabetes, 12 weeks, BMJ Open Diabetes Research & Care, 2020 | No change in weight |
Lawsuits and FDA letters
Buyers have filed 8 class actions over the GLP-1 claims on the products above since March 2025, and 4 are still open. Each date in the table links to the court's docket. A lawsuit is an allegation until a court rules on it. The FDA has also written to sellers whose products were advertised with GLP-1 claims:
- December 10, 2024: The FDA told the seller of Veronvy weight-loss drops, advertised with “The Science of GLP-1,” that they are unapproved new drugs.
- March 31, 2026: The FDA told an eBay seller that its “GLP-1 Weight Control Oral Solution” is an unapproved new drug.
What the drug costs instead
A GLP-1 drug needs a prescription. Every price here is a monthly cash price with no insurance. The cheapest on our chart is $149 a month, with auto-refill, at Strut Health, for compounded semaglutide. Novo Nordisk sells the Wegovy pill for $149 a month at the 1.5 mg starting dose and $299 at the dose you stay on. Eli Lilly sells Zepbound for $299 to $449 a month by dose.
The chart ranks every program by what it charges each month, and GLP-1 without insurance lays out the three ways to pay.
Frequently asked questions
Do GLP-1 supplements work?
None of them is a GLP-1 drug. Pendulum's own page says its probiotic is not intended for weight loss, and Codeage's says do not use its capsules for weight reduction. In the published studies of the ingredients, weight moved by a few pounds or not at all, against 14 to 21 percent of body weight in the drug trials.
Is berberine nature's Ozempic?
No. Berberine is a plant compound, not a GLP-1 drug. A 2025 review of 23 trials found 0.88 kg, about 2 pounds, more weight lost than the comparison group.
Do GLP-1 patches work?
No published study in people shows that any supplement patch works. Two sellers of GLP-1 patches have faced class actions, and some of these patches are now sold as berberine patches.
What does a real GLP-1 cost without insurance?
The lowest cash price GLP Chart tracks is $149 a month, with auto-refill, at Strut Health, for compounded semaglutide, a pharmacy-made version that is not FDA-approved and is not Wegovy, Ozempic, Zepbound or Mounjaro. The Wegovy pill from NovoCare is $149 a month at the 1.5 mg starting dose and $299 at the dose you stay on. Zepbound from LillyDirect is $299 to $449 a month by dose. Prices checked September 28, 2026.
Sources
Evidence checked September 28, 2026
Every figure above is taken from the document beside it, the FDA label or the trial that produced it, so you can read the source instead of trusting us. No clinician reviews these pages. What that means.
11 documents
- Wegovy shot (semaglutide 2.4 mg a week)Wilding JPH et al. N Engl J Med 2021;384(11):989-1002
- Zepbound (tirzepatide 15 mg a week)Jastreboff AM et al. N Engl J Med 2022;387(3):205-216
- Wegovy pill (semaglutide 25 mg a day)Wharton S et al. N Engl J Med 2025;393(11):1077-1087
- Berberine23 trials pooled, International Journal of Obesity, 2025
- Blood orange extract (Morosil, in Lemme)180 adults, 6 months, Nutrients, 2022
- Resistant starch, 40 grams a day37 adults, 8 weeks, Nature Metabolism, 2024
- Lemon extract (Eriomin, in Lemme)103 adults with prediabetes, 12 weeks, Phytotherapy Research, 2019
- Pendulum’s five-strain formula76 adults with type 2 diabetes, 12 weeks, BMJ Open Diabetes Research & Care, 2020
- Supplement patchesWhite CM et al. Annals of Pharmacotherapy 2026;60(8):813-816
- The FDA told the seller of Veronvy weight-loss drops, advertised with “The Science of GLP-1,” that they are unapproved new drugs.FDA warning letter, 2024-12-10
- The FDA told an eBay seller that its “GLP-1 Weight Control Oral Solution” is an unapproved new drug.FDA warning letter, 2026-03-31
Why you can trust GLP Chart. Same scoring framework applied to every program. No paid placements. We never remove unfavorable information at an advertiser's request. Pricing is pulled from each program's public-facing page every Monday.