Checked October 27, 2026
Zepbound 2.5mg costs $299 a month from LillyDirect
The Zepbound 2.5mg starting dose costs $299 a month from LillyDirect, the same for 4 single-dose vials or 1 KwikPen.
Lilly says "2.5 mg is a starting dose and is not approved as a maintenance dose". The next step, 5mg, costs $399: $100 a month more.
There is no refill window at 2.5mg. The 45-day rule starts at 7.5mg.
| Form | A month | A month is | Where |
|---|---|---|---|
| Single-dose vial | $299 | 4 single-dose vials, 28 days | LillyDirect only, self-pay only |
| KwikPen | $299 | 1 four-dose KwikPen, 28 days | LillyDirect, self-pay |
Source: LillyDirect's Zepbound page, checked October 27, 2026. How we check.
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What each step costs after 2.5mg
| Dose | If you refill within 45 days | Otherwise |
|---|---|---|
| 2.5mg | $299 | $299 |
| 5mg | $399 | $399 |
| 7.5mg | $449 | $499 |
| 10mg | $449 | $699 |
| 12.5mg | $449 | $699 |
| 15mg | $449 | $699 |
Questions
How much is Zepbound 2.5mg without insurance?
$299 a month from LillyDirect, for 4 single-dose vials or 1 KwikPen. Read on LillyDirect's Zepbound page on October 27, 2026.
Is 2.5mg a maintenance dose?
Lilly's own page says "2.5 mg is a starting dose and is not approved as a maintenance dose."
How much more is Zepbound 5mg?
5mg is $399 a month, $100 more than 2.5mg.
Is the 2.5mg vial cheaper than the KwikPen?
No. LillyDirect charges $299 a month for either.
Related prices
- Every Zepbound price
- Zepbound dose steps
- LillyDirect prices and how to order
- Zepbound KwikPen cost by dose
- Zepbound 5mg cost
- Zepbound 7.5mg cost
- Zepbound 10mg to 15mg cost
- Zepbound vial cost
This page compares published prices. No clinician reviewed it, and it is not medical advice. GLP Chart is not a medical provider.