What are semaglutide salt forms?
Semaglutide sodium and semaglutide acetate are salt forms: different active ingredients from the semaglutide base in Wegovy and Ozempic. The FDA says salt forms should not be used to compound semaglutide and has warned sellers that use them.
What the FDA has said
The FDA has said it is not aware of any basis for compounding semaglutide with a salt form, because the approved drugs use the base form, and it has received reports of adverse events tied to compounded semaglutide. It has sent warning letters to sellers of semaglutide sodium and acetate products.
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What it means for the price
A low price does not tell you which form a pharmacy uses. Ask a compounded program which form its pharmacy uses, and whether the pharmacy is a 503A pharmacy or a 503B outsourcing facility, before comparing monthly prices.
Questions
Is semaglutide sodium the same as Wegovy?
No. Semaglutide sodium is a salt form, a different active ingredient from the semaglutide in Wegovy and Ozempic, and the FDA says it should not be used to compound semaglutide.
How do I know which form my compounded semaglutide is?
Ask the program or its pharmacy, and read the vial label and the pharmacy's certificate of analysis if it provides one.
Sources
- FDA, Medications containing semaglutide marketed for type 2 diabetes or weight loss
- FDA, Concerns with unapproved GLP-1 drugs used for weight loss
Prices on GLP Chart are read from each program's own pricing page. How: how we check prices. Every program's price this month: the GLP-1 price index.