Compounded versus branded GLP-1 spread
The gap between the cheapest verified compounded route and the cheapest verified branded route, month by month.
The numbers
- Branded cost $100 a month more than compounded semaglutide at the cheapest verified route in September 2026.
- The cheapest verified branded route cost 1.5 times the cheapest verified compounded route in September 2026.
- 9 of the 20 cash-pay programs in the index offer a compounded route. (GLP Chart price index, October 5, 2026)
- 11 of the 20 sell branded medication only. (GLP Chart price index, October 5, 2026)
- A month of branded Wegovy costs a US retail pharmacy $1,302 to acquire, against $299 for the cheapest verified cash route. (CMS National Average Drug Acquisition Cost, effective August 19, 2026, joined to the GLP Chart price index. NADAC is an acquisition-cost benchmark, not pharmacy margin. NADAC dashboards have been published free by 46brooklyn Research since 2019, August 19, 2026)
Source: GLP Chart GLP-1 Cash Price Index, checked October 4, 2026, except where noted.
Two cash programs to check.
No insurance needed.
- Strut Health$149 a month, with auto-refillcompounded semaglutideCheck price →You pick Weight Loss, then a five-minute online visit
- Shed$199 a month30% off first month with code Shed10compounded semaglutideCheck price →A health form first, then you choose your plan
The spread, month by month
| Month | Compounded floor | Branded floor | Gap | Branded to compounded |
|---|---|---|---|---|
| 2026-05 | - | $299/mo | - | - |
| 2026-06 | $199/mo | $299/mo | $100/mo | 1.5x |
| 2026-07 | $199/mo | $299/mo | $100/mo | 1.5x |
| 2026-08 | $199/mo | $299/mo | $100/mo | 1.5x |
| 2026-09 | $199/mo | $299/mo | $100/mo | 1.5x |
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Cite or embed this
Compounded versus branded GLP-1 spread, GLP Chart, October 9, 2026. glpchart.com/stats/compounded-vs-branded-glp1-spread/
<a href="https://glpchart.com/stats/compounded-vs-branded-glp1-spread/">Compounded versus branded GLP-1 spread</a>. Data: GLP Chart, October 9, 2026
Prices behind these figures are checked every Monday. The current numbers live on the price index, and the dated monthly release is the GLP-1 Cash Price Index, October 2026. For any other cut of the data, email press@glpchart.com and you will have it within 24 hours.
The other statistics pages
- GLP-1 prices by state. What the cheapest verified cash GLP-1 route costs in each US state, and which states have fewer programs to choose from.
- GLP-1 cash prices over time. Every month since the weekly record opened, with the compounded and branded floors beside it.
- GLP-1 insurance coverage by payer. How 21 US insurers treat GLP-1s across the payer policies GLP Chart has read.
- Medicaid GLP-1 coverage by state. What each state Medicaid program covers, read from its own preferred drug list.
- Medicare GLP-1 Bridge statistics. The price, the covered products and the dates of the CMS GLP-1 Bridge, plus the figure nobody has published.
- GLP-1 shortage history. What the FDA shortage database says about each GLP-1 molecule today.