A study testing whether an investigational medicine from Novo Nordisk, NNC0721-8060, can help people lose weight.

Who can join
Adults 18 to 55, are overweight, BMI 27+.
What you take
NNC0721-8060, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
How long it lasts
The study runs about 13 months.
What you get
Many clinical trials pay for the study medication and the study visits. Some also pay for travel. Ask the study team what this one covers before you sign the consent form.
Phase Phase 1Sponsor Novo Nordisk A/SDrug NNC0721-8060Class OtherSites 2 USEnrollment target 142

What this study is for

Primary condition: Overweight. Also studied in: Obesity.

Full scientific study title: A First-in-human Research Study on How NNC0721-8060 Works in People Living With Overweight or Obesity.

Who can join

Age18 to 55SexAnyBMI27 to 34.9

Adults 18 to 55, are overweight, BMI 27+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

  • Male or female (sex at birth).
  • Age 18-55 years (both inclusive) at the time of signing informed consent.
  • Body Mass Index (BMI) 27.0-34.9 kilograms per square metre (kg/m\^2) (both inclusive) at screening, with overweight due to excess adipose tissue as judged by the investigator.
  • Considered eligible based on medical history, physical examination, vital signs, electrocardiogram and clinical laboratory tests at screening, as judged by the investigator.

Key exclusion criteria

  • Known or suspected hypersensitivity to study intervention(s) or related products.
  • Previous randomisation in this study.
  • History of allergies (with the exception of seasonal allergies) or history of anaphylactic reactions.
  • Female who is pregnant, breastfeeding, intends to become pregnant, or is of childbearing potential and not using adequate contraception.
  • Current participation (signed informed consent) in any other interventional clinical study.

Where this trial runs

This trial has 2 sites across 2 states. Site contacts are listed for reference. They are not screening through this trial right now.

Kansas1 site
  • ICON Early Phase Services, LLC
    Lenexa, Kansas
Texas1 site
  • ICON
    San Antonio, Texas

Timeline

Scheduled start: August 12, 2026. Expected completion: September 23, 2027. Last updated on ClinicalTrials.gov: August 17, 2026.

Official source

Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked August 19, 2026. Confirm the current status there before you contact a site:

View on ClinicalTrials.gov →

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