A study testing whether a GLP-1 medicine, semaglutide, can help people with glp1 agonist ease back pain and lose weight.
- Who can join
- Adults 18 to 85, have lower back pain, BMI 30+.
- What you take
- semaglutide, given as part of the study. Some participants may receive a placebo (an inactive version) instead, decided at random.
- How long it lasts
- The full study runs about 4.6 years; your own time in it is usually shorter.
- What you get
- Many clinical trials pay for the study medication and the study visits. Some also pay for travel. Ask the study team what this one covers before you sign the consent form.
What this study is for
Primary condition: Lower Back Pain. Also studied in: Obesity (BMI>30), Chronic Lower Back Pain, glp1 Agonist.
Full scientific study title: Semaglutide for Low Back Pain.
Who can join
Adults 18 to 85, have lower back pain, BMI 30+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- Ability to provide informed consent before any trial-related activities
- Age: 18-85 years
- Chronic low back pain, defined as an average low back pain severity of at least 4/10 present on most days for 3 months or longer.
- BMI: 30-49 kg/m2
Key exclusion criteria
- Known or suspected allergy to trial medication(s), excipients, or related products
- Contraindications to study medication(s), worded specifically as stated in the product's Prescribing Information
- Previous randomization in this trial
- Pregnant, breastfeeding, or the intention of becoming pregnant or not using adequate contraceptive measures
- Low back pain related to infection, trauma, or malignancy
Where this trial runs
This trial has 2 sites across 2 states. Site contacts are listed for reference. They are not screening through this trial right now.
Alabama1 site
- The University of Alabama at BirminghamBirmingham, Alabama
Missouri1 site
- Washington University School of MedicineSt Louis, Missouri
Timeline
Scheduled start: February 1, 2027. Expected completion: September 1, 2031. Last updated on ClinicalTrials.gov: July 28, 2026.
Official source
Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked August 10, 2026. Confirm the current status there before you contact a site:
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