A study testing whether a new weekly shot from Lilly, retatrutide, can help with weight.

Who can join

Adults 18+, have obesity who also have ongoing low back pain, BMI 27+.

What you take

retatrutide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.

How long it lasts

The full study runs about 2.3 years; your own time in it is usually shorter.

What you get

The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

What this study is for

Full study title: A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain.

Primary condition: Obesity. Also studied in: Overweight, Chronic Low Back Pain (CLBP).

Who can join, in detail

Key inclusion criteria

• Have a history of axial-predominant low back pain
• Have pain that is restricted to the low back or with a referral pattern limited to the proximal legs
• Have a body mass index (BMI) >=27 kilograms per square meter (kg/m2) at screening
• Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight

Key exclusion criteria

• Have a non-axial origin low back pain
• Have had botulinum or steroid injections to the spine within 1 year of screening
• Have had trigger point injection to the spine within 6 months of screening
• Have a self-reported change in body weight >5 kilograms (kg) (11 pounds) within 90 days prior to screening
• Have been taking drugs to promote body weight reduction, including over-the-counter medications, within 90 days prior to screening

Where this study is enrolling

This trial has 25 US sites across 14 states. Contact the site coordinator directly to start the screening process.

Timeline

Started enrolling: 2025-05-29. Expected completion: 2027-09. Last updated on ClinicalTrials.gov: 2026-05-20.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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