A study testing whether a new weekly shot from Gan and Lee Pharmaceuticals, USA, tirzepatide, can help with weight.

Who can join

Adults 18 to 75, have obesity or are overweight, BMI 27+.

What you take

tirzepatide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.

How long it lasts

The study runs about 16 months.

What you get

The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

What this study is for

Full study title: Efficacy and Safety of GZR18 Every 2 Weeks Versus Tirzepatide and Placebo in Obese or Overweight Participants.

Primary condition: Obesity and Overweight.

Who can join, in detail

Key inclusion criteria

• 18 to 75 years of age (both inclusive) at the time of signing the informed consent form (ICF).
• History of failing to lose sufficient weight with lifestyle/dietary modification.
• Hypertension: defined as taking blood pressure (BP) lowering medication or have a systolic blood pressure (SBP) of >=130 mmHg or a diastolic blood pressure (DBP) of >=80 mmHg at screening.
• Dyslipidemia: defined as taking lipid-lowering medication or have LDL >=160 mg/dL (4.1 mmol/L) or triglycerides >=150 mg/dL (1.7 mmol/L), or high-density lipoprotein (HDL) <40 mg/dL (1.0 mmol/L) for men or HDL <50 mg/dL (1.3 mmol/L) for women at screening.
• Obstructive sleep apnea.

Key exclusion criteria

Where this study is enrolling

This trial has 20 US sites across 9 states. Contact the site coordinator directly to start the screening process.

Timeline

Started enrolling: 2025-02-12. Expected completion: 2026-06-22. Last updated on ClinicalTrials.gov: 2025-02-04.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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