Prices verified June 22, 2026
Head-to-head

Medvi vs Costco / Success by Sesame: GLP-1 weight loss comparison 2026

Medvi comes out ahead overall (7.8 vs 7.6/10). The right pick still depends on your situation.

MedviOur pick
Medvi logo
Score: 7.8 out of 10
7.8
out of 10
Flat refill price that holds as your dose climbs.
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Costco / Success by Sesame
Costco / Success by Sesame logo
Score: 7.6 out of 10
7.6
out of 10
Discounted member care plus brand-name medication at Costco.
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Quick verdict

Medvi is the better pick for most patients on overall scoring. Medvi runs a compounded-semaglutide and tirzepatide model at flat monthly pricing, with no lock-in and rapid intake. Comparable to Henry Meds and Mochi on price; less established clinical depth than Form Health or Knownwell. Best fit for cash-pay patients who want predictable monthly cost with minimal friction.

That said, Costco / Success by Sesame wins on specific dimensions. Costco bundles Success by Sesame care with discounted self-pay branded GLP-1 at Costco Pharmacy. The medication price is genuinely low for a brand-name pen: the Wegovy or Ozempic injection is $349/mo self-pay, with care from $59/mo on the annual plan. The catch is a paid Costco membership, and the bundle has no member outcome record yet.

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Side-by-side

MedviCostco / Success by Sesame
Starts from$299/mo (incl. medication)$408/mo (incl. medication)
Monthly cost gapMedvi is $29/mo cheaper than Costco / Success by Sesame
Lock-inMonth-to-monthMonth-to-month
Time to prescription2 days2 days
Consultation typeAsynchronousVideo
Affiliate networkDirectCJ

Score by dimension

Scores out of 10, equal-weighted across five dimensions. How we score. The winner of each dimension is highlighted.

MedviCostco / Success by Sesame
Pricing transparency8/107/10
Cancellation terms8/108/10
Onboarding experience7/107/10
Medication options7/107/10
Member reviews9/109/10

When to choose Medvi

Best for flat compounded with no lock-in

Cash-pay patients who want flat predictable compounded GLP-1 pricing with no lock-in and same-week onboarding. Strong fit if you've taken GLP-1 before and want a simple ongoing prescription channel.

Medvi wins on pricing transparency and runs $29/mo cheaper than Costco / Success by Sesame at the entry tier ($179 vs $208). Over a year that's $348 you keep. The caveat: Insurance-pathway shoppers, patients with multiple comorbidities needing clinical depth or anyone wanting branded Wegovy or Zepbound through standard PA. Note also: Compounded GLP-1 carries 503A regulatory exposure; see compounded callout

When to choose Costco / Success by Sesame

Best for Costco members

Existing Costco members who want discounted self-pay branded GLP-1 with light telehealth care attached.

Costco / Success by Sesame wins on tied dimensions on the dimensional scoring. The caveat: Anyone who is not a Costco member, wants a compounded option, or wants a long member-review track record.

If cost is your main filter

Medvi is the cheaper monthly: $179 all-in vs $208 for Costco / Success by Sesame. That's $29 a month or $348a year. The 12-month math matters most if you're planning to maintain on GLP-1 long-term. If you're running a 3-month trial, the $87 delta is small against the cost of stopping early on the wrong dose. Insurance changes the picture: if either program runs prior auth and your plan covers Wegovy or Zepbound, branded with copay can beat both cash-pay totals.

If lock-in is your main filter

Medvi (month-to-month) and Costco / Success by Sesame (month-to-month) sit at the same cancellation tier. Read both cancellation policies directly before signing; the on-page summary covers the headline but not the deletion-of-account or refund-window edge cases.

FAQ

Is Medvi cheaper than Costco / Success by Sesame?
Medvi starts at $299/mo (medication included). Costco / Success by Sesame starts at $408/mo (medication included). The cheaper option depends on whether you have insurance coverage for branded GLP-1s.
Can I switch from Medvi to Costco / Success by Sesame mid-treatment?
Yes. Both programs accept new patients on existing GLP-1 doses. Bring your current prescription details to the new program's intake. Your titration schedule typically continues from where it left off.
Which program has better member feedback?
Medvi scored 9/10 on member reviews; Costco / Success by Sesame scored 9/10. This pillar is each program's public Trustpilot rating mapped to a 0-10 score. Read Medvi's feedback section or Costco / Success by Sesame's feedback section for the details.

Read the full reviews

All head-to-head comparisons → · Full chart → · Cost guide · Programs guide

Why you can trust GLP ChartSame scoring framework applied to every program. No paid placements. We never remove unfavorable information at an advertiser's request. Pricing is pulled from each program's public-facing page every Monday.