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Quick verdict
LifeMD is the better pick for most patients on overall scoring. Mature publicly-traded telehealth with rare direct-supply deals from both Novo Nordisk and Eli Lilly. Membership is $75 the first month then $149/mo ongoing. The Wegovy pill is $149/mo at starter doses and $299/mo at full doses. Steady-state total runs about $448/mo (starter months about $298, first month $224). Wegovy injection runs higher and Zepbound vials from $349. Insurance navigation included. Opt-in money-back guarantee: stay enrolled 12 months and lose at least 10% body weight, or you're eligible for a refund per posted terms.
That said, Costco / Success by Sesame wins on specific dimensions. Costco bundles Success by Sesame care with discounted self-pay branded GLP-1 at Costco Pharmacy. The medication price is genuinely low for a brand-name pen: the Wegovy or Ozempic injection is $349/mo self-pay, with care from $59/mo on the annual plan. The catch is a paid Costco membership, and the bundle has no member outcome record yet.
Side-by-side
| LifeMD | Costco / Success by Sesame | |
|---|---|---|
| Starts from | $448/mo (+ med separate) | $408/mo (incl. medication) |
| Monthly cost gap | Costco / Success by Sesame is $90/mo cheaper than LifeMD | |
| Lock-in | Month-to-month | Month-to-month |
| Time to prescription | 2 days | 2 days |
| Consultation type | Async | Video |
| Affiliate network | Impact | CJ |
Score by dimension
Scores out of 10, equal-weighted across five dimensions. How we score. The winner of each dimension is highlighted.
| LifeMD | Costco / Success by Sesame | |
|---|---|---|
| Pricing transparency | 8/10 | 7/10 |
| Cancellation terms | 7.5/10 | 8/10 |
| Onboarding experience | 8.5/10 | 7/10 |
| Medication options | 9/10 | 7/10 |
| Member reviews | 8.2/10 | 9/10 |
When to choose LifeMD
Best for insurance plus lifestyle support
Mainstream patients who want insurance navigation plus the option to cash-pay for branded GLP-1 at near-NovoCare/LillyDirect rates without leaving the platform.
LifeMD wins on pricing transparency, onboarding experience, medication options on the dimensional scoring. The caveat: Patients chasing the absolute cheapest compounded option or wanting a pure cash-only flat rate. Note also: Publicly traded NASDAQ:LFMD with formal pharmaceutical supply agreements
When to choose Costco / Success by Sesame
Best for Costco members
Existing Costco members who want discounted self-pay branded GLP-1 with light telehealth care attached.
Costco / Success by Sesame wins on cancellation terms, member reviews and runs $90/mo cheaper than LifeMD at the entry tier ($208 vs $298). Over a year that's $1,080 you keep. The caveat: Anyone who is not a Costco member, wants a compounded option, or wants a long member-review track record.
If cost is your main filter
Costco / Success by Sesame is the cheaper monthly: $208 all-in vs $298 for LifeMD. That's $90 a month or $1,080a year. The 12-month math matters most if you're planning to maintain on GLP-1 long-term. If you're running a 3-month trial, the $270 delta is small against the cost of stopping early on the wrong dose. Insurance changes the picture: if either program runs prior auth and your plan covers Wegovy or Zepbound, branded with copay can beat both cash-pay totals.
If lock-in is your main filter
LifeMD (month-to-month) and Costco / Success by Sesame (month-to-month) sit at the same cancellation tier. Read both cancellation policies directly before signing; the on-page summary covers the headline but not the deletion-of-account or refund-window edge cases.
FAQ
Is LifeMD cheaper than Costco / Success by Sesame?
Can I switch from LifeMD to Costco / Success by Sesame mid-treatment?
Which program has better member feedback?
Read the full reviews
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