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Quick verdict
Costco / Success by Sesame is the better pick for most patients on overall scoring. Costco bundles Success by Sesame care with discounted self-pay branded GLP-1 at Costco Pharmacy. The medication price is genuinely low for a brand-name pen: the Wegovy or Ozempic injection is $349/mo self-pay, with care from $59/mo on the annual plan. The catch is a paid Costco membership, and the bundle has no member outcome record yet.
That said, Amazon Pharmacy wins on specific dimensions. Amazon Pharmacy brings genuine branded GLP-1 to a household name with the clearest cash pricing in the category: the price is published upfront and shown next to your insurance price at checkout. Branded only, no compounded option, and new enough that there is no member outcome record yet.
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Side-by-side
| Amazon Pharmacy | Costco / Success by Sesame | |
|---|---|---|
| Starts from | $149/mo (incl. medication) | $408/mo (incl. medication) |
| Monthly cost gap | Amazon Pharmacy is $59/mo cheaper than Costco / Success by Sesame | |
| Lock-in | No lock-in | Month-to-month |
| Time to prescription | 3 days | 2 days |
| Consultation type | Amazon | Video |
| Affiliate network | Direct | CJ |
Score by dimension
Scores out of 10, equal-weighted across five dimensions. How we score. The winner of each dimension is highlighted.
| Amazon Pharmacy | Costco / Success by Sesame | |
|---|---|---|
| Pricing transparency | 8/10 | 7/10 |
| Cancellation terms | 8/10 | 8/10 |
| Onboarding experience | 6/10 | 7/10 |
| Medication options | 7/10 | 7/10 |
| Member reviews | 3/10 | 9/10 |
When to choose Amazon Pharmacy
Best for branded at a clear cash price
Buyers who want genuine branded Wegovy or Zepbound at a clear, upfront cash price with fast nationwide delivery from a name they already trust.
Amazon Pharmacy wins on pricing transparency and runs $59/mo cheaper than Costco / Success by Sesame at the entry tier ($149 vs $208). Over a year that's $708 you keep. The caveat: Anyone seeking a compounded GLP-1, the rock-bottom cash price, or a long member-review track record.
When to choose Costco / Success by Sesame
Best for Costco members
Existing Costco members who want discounted self-pay branded GLP-1 with light telehealth care attached.
Costco / Success by Sesame wins on onboarding experience, member reviews on the dimensional scoring. The caveat: Anyone who is not a Costco member, wants a compounded option, or wants a long member-review track record.
If cost is your main filter
Amazon Pharmacy is the cheaper monthly: $149 all-in vs $208 for Costco / Success by Sesame. That's $59 a month or $708a year. The 12-month math matters most if you're planning to maintain on GLP-1 long-term. If you're running a 3-month trial, the $177 delta is small against the cost of stopping early on the wrong dose. Insurance changes the picture: if either program runs prior auth and your plan covers Wegovy or Zepbound, branded with copay can beat both cash-pay totals.
If lock-in is your main filter
Amazon Pharmacy (no lock-in) and Costco / Success by Sesame (month-to-month) sit at the same cancellation tier. Read both cancellation policies directly before signing; the on-page summary covers the headline but not the deletion-of-account or refund-window edge cases.
FAQ
Is Amazon Pharmacy cheaper than Costco / Success by Sesame?
Can I switch from Amazon Pharmacy to Costco / Success by Sesame mid-treatment?
Which program has better member feedback?
Read the full reviews
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