A study testing whether a GLP-1 medicine from Eccogene, semaglutide, can help with weight.

Who can join

Adults 18 to 75, have obesity, BMI 30+.

What you take

semaglutide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.

How long it lasts

The study runs about 8 months.

What you get

The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

What this study is for

Full study title: MIST (Metabolic Intervention With Semaglutide and THR-β Therapy) Trial.

Primary condition: Adult Obesity. Also studied in: Weight Management.

Who can join, in detail

Key inclusion criteria

• Capable of providing written informed consent and complying with all trial procedures.
• Willing to comply with contraception requirements (as applicable to males and females of childbearing potential).
• Obese with BMI >=30 kg/m^2 and stable body weight within 6 months prior to screening.
• HbA1c <=6.5%.
• Estimated glomerular filtration rate (eGFR) >=60 mL/min/1.73 m^2 (per CKD-EPI 2021 formula).

Key exclusion criteria

• History or current diagnosis of type 1 or type 2 diabetes mellitus.
• Weight change >5% of total body weight within 6 months prior to screening or planned initiation of a weight loss program or use of weight-altering medication.
• Obesity induced by endocrine disorders such as Cushing's syndrome or monogenic or syndromic obesity such as Prader-Willi syndrome.
• Use of GLP-1 agonist treatment within the last 6 months prior to screening.
• History or current evidence of a pituitary disorder.

Where this study is enrolling

This trial has 15 US sites across 10 states. Contact the site coordinator directly to start the screening process.

Timeline

Started enrolling: 2026-03-13. Expected completion: 2026-11-20. Last updated on ClinicalTrials.gov: 2026-04-01.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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