A study testing whether a study medicine from Novo Nordisk, cagrisema, can help with weight.

Who can join

Adults 18+, are overweight, BMI 27+.

What you take

cagrisema, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.

How long it lasts

The full study runs about 1.6 years; your own time in it is usually shorter.

What you get

The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

What this study is for

Full study title: A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body Weight.

Primary condition: Overweight. Also studied in: Obesity.

Who can join, in detail

Key inclusion criteria

• Male or female (sex at birth)
• Age 18 years or above at the time of signing the informing consent.
• Body Mass Index (BMI) is greater than or equal to (>= ) 30.0 kilograms per square metre (kg/m^2) or BMI >= 27.0 kg/m^2 with the presence of at least one obesity-related complication including, but not limited to, hypertension, dyslipidaemia, obstructive sleep apnoea or cardiovascular disease.

Key exclusion criteria

• Glycosylated haemoglobin (HbA1c) >= 6.5 % (48 millimoles per mole [mmol/mol]) as measured by the central laboratory at screening.
• History of type 1 or type 2 diabetes.
• Previous exposure to CagriSema in a clinical study.

Where this study is enrolling

This trial has 26 US sites across 16 states. Contact the site coordinator directly to start the screening process.

Timeline

Started enrolling: 2026-06-22. Expected completion: 2028-01-17. Last updated on ClinicalTrials.gov: 2026-02-25.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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