A study testing whether a GLP-1 medicine from Lilly, orforglipron, can lower blood pressure.

Who can join

Adults 18+, have high blood pressure, BMI 25+.

What you take

orforglipron, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.

How long it lasts

The full study runs about 2.4 years; your own time in it is usually shorter.

What you get

The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

What this study is for

Full study title: A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening).

Primary condition: Hypertension.

Who can join, in detail

Key inclusion criteria

• Has systolic blood pressure (SBP) >= 140 mmHg and/or diastolic blood pressure (DBP) >= 90 mmHg (if DBP criteria alone is met, SBP must be >=130 mmHg) at screening (Visit 1).
• Has SBP >= 140 mmHg and/or DBP >= 90 mmHg (if DBP criteria alone is met, SBP must be >=130 mmHg) at week 0 (Visit 3).
• Untreated for hypertension, or on stable antihypertensive medications >= 30 days prior to Visit 1.
• Have a body mass index (BMI) >= 25 kg/m².

Key exclusion criteria

• Has SBP >=170 mmHg and/or DBP >=110 mmHg at Visit 1 or at Visit 3.
• Has known secondary causes of hypertension
• Have heart failure with reduced ejection fraction (HFrEF) diagnosis
• Have had any of the following conditions within 90 days prior to screening.
• hospitalization for hypertension or for congestive heart failure

Where this study is enrolling

This trial has 29 US sites across 18 states. Contact the site coordinator directly to start the screening process.

Timeline

Started enrolling: 2025-04-30. Expected completion: 2027-09. Last updated on ClinicalTrials.gov: 2026-05-12.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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John Samaras, Founder and editorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas. About this site · LinkedIn · Contact