A study in people with diabetes.

Who can join: Adults 18+, have diabetes, BMI 30+.
What you take: Check ClinicalTrials.gov for this trial's study groups and what each group receives.
How long it lasts: The full study runs about 2 years.
What you get: Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.

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Phase Not ApplicableSponsor The Cleveland ClinicDrug investigational drugClass OtherSites 1 USEnrollment target 20

What this study is for

Primary condition: Diabetes.

Full scientific study title: Whole Gut Motility Abnormalities Following GLP-1 Receptor Agonist (GLP-1RA) Initiation.

Who can join

Age18 and upSexAnyBMI30 or higher

Adults 18+, have diabetes, BMI 30+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

Adult patients (18 years or older)
Initiating GLP-1RA or GLP-1RA/GIP (dual agonist) therapy, or off GLP-1RA or GLP1-RA/GIP therapy for greater than 3 months for the treatment of type 2 diabetes with or without obesity (BMI \> 30 kg/m2) at the time of the baseline visit
Stable glucose control (HbA1c ≤ 9%) within 6 months of the baseline visit
Normal TSH within 6 months of baseline visit

Key exclusion criteria

Current use of opiates, marijuana, anticholinergics, or pro-motility medications. Can be included if there is no utilization for at least 1 month.
Use of antibiotics within the past 2 weeks
History of gastric or bowel surgery
Known or suspected history or active intestinal obstruction or stricture
Pregnancy

Where this trial runs

This trial has 1 sites across 1 state. Site contacts are listed for reference. They are not screening through this trial right now.

Ohio1 site

Cleveland Clinic
Cleveland, Ohio
Samita Garg, MD216-444-2384GARGS@ccf.org

Follow this trial

We email you if NCT07784127 changes status, adds new sites in your state, or if a similar trial opens for the same condition.

Timeline

Scheduled start: December 2026. Expected completion: December 2028. Last updated on ClinicalTrials.gov: August 25, 2026.

Official source

Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:

View on ClinicalTrials.gov →

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John Samaras, Founder and EditorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas.
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