A study testing whether a study medicine can help people with type 2 diabetes lower blood sugar and lose weight.
- Who can join
- Adults 65 to 85, have type 2 diabetes.
- What you take
- Check ClinicalTrials.gov for this trial's study groups and what each group receives.
- How long it lasts
- The full study runs about 4 years.
- What you get
- Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.
What this study is for
Primary condition: Type 2 Diabetes Mellitus (T2DM). Also studied in: Sarcopenia, Obesity, Muscle Loss, Older Adults.
Full scientific study title: HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide.
Who can join
Adults 65 to 85, have type 2 diabetes. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- Age 65 to 85 years, inclusive.
- Type 2 diabetes mellitus, defined by HbA1c at or above 6.5% or current use of antihyperglycemic medication.
- Body mass index at or above 27 kg/m2.
- Newly initiating semaglutide as standard clinical care under the direction of a treating clinician.
- Able to walk 400 meters without assistance; use of a cane is permitted.
Key exclusion criteria
- Estimated glomerular filtration rate below 45 mL/min/1.73 m2.
- Use of HMB, creatine, or high-dose whey protein supplements within the previous 3 months.
- Weight change greater than 5% during the previous 3 months.
- Recent fracture within the previous 6 months.
- Neuromuscular disease, including Parkinson disease, or another condition that would interfere with study outcomes or safe participation.
Where this trial runs
This trial has 1 sites across 1 state. Site contacts are listed for reference. They are not screening through this trial right now.
Tennessee1 site
- Vanderbilt University Medical CenterNashville, Tennessee
Timeline
Scheduled start: December 1, 2026. Expected completion: November 2030. Last updated on ClinicalTrials.gov: August 28, 2026.
Official source
Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:
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