A study testing whether a new weekly shot, tirzepatide, can help people quit smoking.

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

• Age 21-65 years
• Body mass index ≥ 25kg/m2 at the baseline screening
• Reporting ≥10 cigarettes per day, on average, for the past 6 months and \> 2 year duration of smoking
• Interest in making a long-term cessation attempt within the next 30-60 days
• Willingness to receive study medication and standard-of-care smoking cessation supports (nicotine replacement therapy and a smoking cessation app)

Key exclusion criteria

• BMI \< 25 kg/m2 at screening
• History of diabetes, diabetes-attributable medical conditions, or HbA1c ≥6.5% at baseline
• Recent (past 90 days) active suicidal ideation or lifetime history of suicide attempt
• Current treatment for psychotic disorders or mood disorders with psychotic features (e.g., schizophrenia, schizoaffective disorder, depression with psychotic features), current treatment for bipolar disorder (with or without psychotic features), or current secondary psychosis due to substance use or another medical condition
• Meeting DSM-5 criteria for a current (past 12 months) substance use disorder other than tobacco use disorder, mild or moderate cannabis use disorder, or mild or moderate alcohol use disorder.