Home›Clinical trials›A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without

A study testing whether a study medicine from Novo Nordisk, cagrisema, can help people lose weight.

Recruiting now. Registry record last updated July 30, 2026.

Who can join
Adults 18+, have obesity, BMI 35+.
What you take
cagrisema, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
How long it lasts
The full study runs about 1.9 years; your own time in it is usually shorter.
What you get
Many clinical trials pay for the study medication and the study visits. Some also pay for travel. Ask the study team what this one covers before you sign the consent form.
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Phase Phase 3Sponsor Novo Nordisk A/SDrug cagrisemaClass OtherSites 99 USEnrollment target 2,500

What this study is for

Primary condition: Obesity. Also studied in: Type 2 Diabetes.

Full scientific study title: A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without.

Who can join

Age18 and upSexAnyBMI35 or higher

Adults 18+, have obesity, BMI 35+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

  • Male or female (sex assigned at birth, inclusive of all gender identities).
  • Age 18 years or above at the time of signing the informed consent.
  • BMI≥ 35.0 kg/m\^2.
  • Participants without T2D: No history of T2D and HbA1c \< 6.5% (48 millimoles per mole (mmol/mol)) Participants with T2D: A history of T2D and HbA1c \< 10% (\< 86 mmol/mol). If a participant without a history of diabetes during the screening period receives an HbA1c result of 6.5% (48 mmol/mol) or higher, the investigator or the participant's healthcare provider must confirm the diagnosis of type 2 diabetes before the participant is randomised.

Key exclusion criteria

  • A self-reported change in body weight \> 5% within 90 days before screening, irrespective of medical records.
  • Use of any glucagon-like-peptide-1 receptor agonist (GLP-1 RA), including medication with GLP-1 RA activity, or amylin analogues, including medication with amylin activity, within 6 months before screening.

Where this trial is enrolling

This trial has 99 sites across 30 states. Contact a site coordinator directly to start screening.

Alabama2 sites
  • Uni of Alabama at Birmingham
    Birmingham, Alabama
  • Cahaba Research
    Pelham, Alabama
Arizona2 sites
  • Elligo Health Research Inc
    Gilbert, Arizona
  • Velocity Clinical Research-Phoenix
    Phoenix, Arizona
Arkansas2 sites
  • Arkansas Clinical Research
    Little Rock, Arkansas
  • Woodland Int. Research Group
    Little Rock, Arkansas
California11 sites
  • Headlands Research California, LLC
    Escondido, California
  • Neighborhood Healthcare
    Escondido, California
  • Diabetes & Endocrine Specialists - La Mesa
    La Mesa, California
  • Clinical Trials Research_Sacramento
    Lincoln, California
  • Loma Linda University Faculty Medical Clinics
    Loma Linda, California
  • Pacific Clinical Studies
    Los Alamitos, California
  • Valley Clinical Trials
    Northridge, California
  • Desert Oasis Healthcare
    Palm Springs, California
  • Linda Vista Health Care Ctr
    San Diego, California
  • Velocity Clin Res - Van Nuys
    Van Nuys, California
  • Flourish Research - CA
    Walnut Creek, California
Colorado1 site
  • University of Colorado Hospital
    Aurora, Colorado
Florida10 sites
  • TBMR & Alcanza
    Clearwater, Florida
  • Northeast Research Institute
    Fleming Island, Florida
  • Northeast Research Institute
    Jacksonville, Florida
  • Westside Center For Clinical Research
    Jacksonville, Florida
  • Bioclinical Research Alliance
    Miami, Florida
  • New Horizon Research Center
    Miami, Florida
  • South Broward Research LLC
    Miramar, Florida
  • West Orange Endocrinology
    Ocoee, Florida
  • Oviedo Medical Research, LLC
    Oviedo, Florida
  • Clinical Trial Services Corp
    Pembroke Pines, Florida
Georgia4 sites
  • Hope Clin Res & Wellness
    Conyers, Georgia
  • Center for Adv Res & Education
    Gainesville, Georgia
  • Endocrine Research Solutions, Inc
    Roswell, Georgia
  • North Georgia Clinical Research
    Woodstock, Georgia
Idaho1 site
  • Solaris Clinical Research
    Meridian, Idaho
Illinois5 sites
  • Cedar-Crosse Research Center
    Chicago, Illinois
  • Macoupin Fam Practice Ctr, LLP
    Gillespie, Illinois
  • Clinical Investigation Spec Gurnee
    Gurnee, Illinois
  • Endeavor Health
    Skokie, Illinois
  • Evanston Premier Hlthcr Res
    Skokie, Illinois
Iowa1 site
  • Iowa Diabetes Research
    West Des Moines, Iowa
Kansas2 sites
  • Alliance for Multispecialty Research
    Newton, Kansas
  • Cotton O'Neil Diab & Endo Ctr
    Topeka, Kansas
Kentucky1 site
  • The Research Group of Lexington LLC
    Lexington, Kentucky
Maryland1 site
  • Endo and Metabolic Consultants
    Rockville, Maryland
Michigan1 site
  • Northern Pines Hlth Ctr, PC
    Buckley, Michigan
Minnesota2 sites
  • International Diabetes Center
    Minneapolis, Minnesota
  • AES Minneapolis DRS
    Richfield, Minnesota
Mississippi1 site
  • Belzoni Clinical Research
    Belzoni, Mississippi
Missouri2 sites
  • Clinical Research Professionals
    Chesterfield, Missouri
  • Amicis Centers of Clinical Research
    St Louis, Missouri
New York1 site
  • Southgate Medical Group, LLP
    West Seneca, New York
North Carolina6 sites
  • PharmQuest Life Sciences LLC
    Greensboro, North Carolina
  • Physician's East Endocrinology
    Greenville, North Carolina
  • Carteret Medical Group
    Morehead City, North Carolina
  • Centricity Rsrch MHCity Multi
    Morehead City, North Carolina
  • Piedmont Healthcare/Research
    Statesville, North Carolina
  • Accellacare Wilmington
    Wilmington, North Carolina
North Dakota2 sites
  • Lillestol Research LLC
    Fargo, North Dakota
  • Plains Clinical Research Center, LLC
    Fargo, North Dakota
Ohio1 site
  • Advanced Medical Research
    Maumee, Ohio
Oklahoma2 sites
  • Alliance for Multispecialty Research
    Norman, Oklahoma
  • Lynn Institute of Norman
    Norman, Oklahoma
Pennsylvania3 sites
  • Heritage Valley Medical Group
    Beaver, Pennsylvania
  • Hatboro Med Associates
    Hatboro, Pennsylvania
  • Northeast Endocrine Metabolic Associates
    Philadelphia, Pennsylvania
Rhode Island1 site
  • Clinical Res Collaborative
    Cumberland, Rhode Island
South Carolina2 sites
  • Velocity Clinical Research-Gaffney
    Gaffney, South Carolina
  • Spartanburg Medical Research
    Spartanburg, South Carolina
Tennessee5 sites
  • Jackson Clinic
    Jackson, Tennessee
  • Holston Medical Group
    Kingsport, Tennessee
  • CNS Healthcare
    Memphis, Tennessee
  • HealthStar Physicians, PC
    Morristown, Tennessee
  • Clinical Research Associates
    Nashville, Tennessee
Texas19 sites
  • Amarillo Med Spec LLP
    Amarillo, Texas
  • Texas Diab & Endo, P.A.
    Austin, Texas
  • Velocity Clinical Research Austin
    Austin, Texas
  • Velocity Clin Res, Dallas
    Dallas, Texas
  • North Texas Endocrine Center
    Dallas, Texas
  • Cedar Health Research
    Euless, Texas
  • JCCT- Juno NW Houston
    Houston, Texas
  • The Endocrine Center
    Houston, Texas
  • Medical Colleagues-Texas LLP
    Katy, Texas
  • Sante Clinical Research
    Kerrville, Texas
  • Radiance Clinical Research
    Lampasas, Texas
  • Aeres Clinical Research
    Laredo, Texas
  • DCOL Ctr for Clin Res
    Longview, Texas
  • RGV Endocrine Center
    McAllen, Texas
  • Quality Research Inc
    San Antonio, Texas
  • AES San Antonio
    San Antonio, Texas
  • Northeast Clinical Research of San Antonio
    San Antonio, Texas
  • Consano Clinical Research, LLC
    Shavano Park, Texas
  • Mt Olympus Medical Research, LLC
    Sugar Land, Texas
Utah4 sites
  • J.Lewis Research Inc
    Salt Lake City, Utah
  • J.Lewis Research Inc
    Salt Lake City, Utah
  • Diabetes & Endo Tx Specialists
    Sandy City, Utah
  • J.Lewis Research Inc
    South Jordan, Utah
Virginia3 sites
  • Health Res of Hampton Roads
    Newport News, Virginia
  • Tidewater Physicians Multispecialty Group
    Newport News, Virginia
  • National Clin Res Inc.
    Richmond, Virginia
Wisconsin1 site
  • Prevea Health
    Green Bay, Wisconsin

Timeline

Started enrolling: May 21, 2026. Expected completion: April 19, 2028. Last updated on ClinicalTrials.gov: July 30, 2026.

Official source

Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked August 21, 2026. Confirm the current status there before you contact a site:

View on ClinicalTrials.gov →

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John Samaras, editor of GLP Chart
John Samaras, Founder and EditorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas.
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