A study testing whether tradipitant from Vanda Pharmaceuticals, an investigational anti-nausea medicine, can reduce nausea and vomiting.

Who can join

Adults 18 to 65, have nausea and vomiting, BMI 25+.

What you take

Tradipitant, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.

How long it lasts

The study runs about 9 months.

What you get

The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

What this study is for

Full study title: A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use.

Primary condition: Nausea and Vomiting. Also studied in: Obesity.

Who can join, in detail

Key inclusion criteria

• Body Mass Index >= 25 and < 40 kg/m^2
• No serious medical problems or chronic diseases, specifically no type I or type II diabetes

Key exclusion criteria

• Another disorder that contributes to gastrointestinal symptoms
• History of intolerance and/or hypersensitivity to NK-1 receptor antagonists
• History of intolerance and/or hypersensitivity to GLP-1 receptor agonists
• Exposure to any investigational medication within the past 60 days

Where this study is enrolling

This trial has 10 US sites across 6 states. Contact the site coordinator directly to start the screening process.

Timeline

Started enrolling: 2026-03-27. Expected completion: 2026-12-01. Last updated on ClinicalTrials.gov: 2026-04-20.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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