A study testing whether a GLP-1 medicine, semaglutide, can help people with type 1 diabetes lower blood sugar.

Who can join: Ages 12 to 70, have type 1 diabetes, BMI 18.5+.
What you take: Semaglutide, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
How long it lasts: The full study runs about 2 years.
What you get: Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.

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Phase Phase 2Sponsor Children's Hospital Medical Center, CincinnatiDrug semaglutideClass GLP-1 RASites 1 USEnrollment target 15

What this study is for

Primary condition: Stage 1 Diabetes Mellitus, Type 1.

Full scientific study title: GLP-1 RA for Stage 1 Type 1 Diabetes.

Who can join

Age12 to 70SexAnyBMI18.5 or higher

Ages 12 to 70, have type 1 diabetes, BMI 18.5+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

Stage 1 Type 1 Diabetes
Screening OGTT with impaired or loss of first phase insulin secretion but no dysglycemia to suggest stage 2 or stage 3 type 1 diabetes

Key exclusion criteria

History of anaphylaxis or allergies to GLP-1 receptor agonists
Already on a GLP-1 receptor agonist
History of bariatric surgery
Personal or family history of cancer such as medullary thyroid cancer
Personal history of pancreatitis or pathogenic variants associated with increased risk of pancreatitis

Where this trial runs

This trial has 1 sites across 1 state. Site contacts are listed for reference. They are not screening through this trial right now.

Ohio1 site

Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio
Lily Deng, MD513-636-0002lily.deng@cchmc.org

Follow this trial

We email you if NCT07430332 changes status, adds new sites in your state, or if a similar trial opens for the same condition.

Timeline

Scheduled start: September 1, 2027. Expected completion: January 1, 2030. Last updated on ClinicalTrials.gov: February 24, 2026.

Official source

Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:

View on ClinicalTrials.gov →

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John Samaras, Founder and EditorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas.
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