Not yet recruiting · NCT07298915

A study testing whether a new weekly shot from University of Virginia, tirzepatide, can help with weight.

Who can join: Adults 30 to 65, have obesity or are overweight, BMI 27+.
What you take: tirzepatide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
How long it lasts: The study runs about 10 months.
What you get: The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

Phase Phase 3Sponsor University of VirginiaDrug tirzepatideClass GLP-1/GIPSites 1 USEnrollment target 24

What this study is for

Full study title: The Effect of Exercise and Tirzepatide on Weight and Health Outcomes (EXER-MED).

Primary condition: Obesity & Overweight.

Who can join, in detail

Age 30 to 65

Sex All

BMI 27 to 40

Key inclusion criteria

Men and women 30-65 years of age, postmenopausal women included
27-29.9 with an additional CVD risk factor or 30-40 kg/m2
For overweight adults only: additional cardiometabolic risk factor (diagnosed dyslipidemia, hypertension)
Willingness and adequate health to go on weight loss medication
The capability and willingness to provide written informed consent

Key exclusion criteria

Including but not limited to serious arrhythmias
Cardiomyopathy
Congestive heart failure
Stroke or transient ischemic attacks
Peripheral vascular disease

Where this study is enrolling

This trial has 1 US sites across 1 states. Contact the site coordinator directly to start the screening process.

Virginia

University of Virginia
Charlottesville, Virginia
Damon L Swift, Ph.D.(434) 924-1436

Follow this trial

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Timeline

Started enrolling: 2026-08. Expected completion: 2027-06. Last updated on ClinicalTrials.gov: 2026-05-06.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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