A study testing whether an investigational medicine from Kailera, KAI-9531, can help people lose weight.
Recruiting now. Registry record last updated July 22, 2026.
- Who can join
- Adults 18+, have obesity, BMI 35+.
- What you take
- KAI-9531, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
- How long it lasts
- The full study runs about 2.3 years; your own time in it is usually shorter.
- What you get
- Many clinical trials pay for the study medication and the study visits. Some also pay for travel. Ask the study team what this one covers before you sign the consent form.
What this study is for
Primary condition: Obesity.
Full scientific study title: Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do .
Who can join
Adults 18+, have obesity, BMI 35+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- BMI ≥35 kilograms per square meter (kg/m\^2).
- History of being unresponsive to at least 1 self-reported effort to lose weight with diet and/or exercise in the last 6 months.
Key exclusion criteria
- Current diagnosis or history of diabetes mellitus.
- Started medications within 3 months prior to Screening that may cause significant weight change, including, but not limited to, tricyclic antidepressants, atypical antipsychotics, mood stabilizers, and phentermine.
- Unstable weight defined as self-reported change in body weight exceeding 5% within the 3 months prior to Screening.
- Family or personal history of multiple endocrine neoplasia Type 2 or medullary thyroid cancer.
- Uncontrolled hypertension or unstable cardiovascular disease.
Where this trial is enrolling
This trial has 27 sites across 19 states. Contact a site coordinator directly to start screening.
Arizona2 sites
- Kailera Clinical SiteGlendale, Arizona
- Kailera Clinical SitePhoenix, Arizona
Arkansas1 site
- Kailera Clinical SiteLittle Rock, Arkansas
California2 sites
- Kailera Clinical SiteNorthridge, California
- Kailera Clinical SiteOceanside, California
Connecticut2 sites
- Kailera Clinical SiteHamden, Connecticut
- Kailera Clinical SiteStamford, Connecticut
Florida1 site
- Kailera Clinical SiteOrange City, Florida
Georgia1 site
- Kailera Clinical SiteAlbany, Georgia
Illinois2 sites
- Kailera Clinical SiteChicago, Illinois
- Kailera Clinical SiteSkokie, Illinois
Kansas1 site
- Kailera Clinical SiteNewton, Kansas
Louisiana1 site
- Kailera Clinical SiteShreveport, Louisiana
Michigan1 site
- Kailera Clinical SiteFarmington Hills, Michigan
Montana1 site
- Kailera Clinical SiteMissoula, Montana
Nevada1 site
- Kailera Clinical SiteLas Vegas, Nevada
New York1 site
- Kailera Clinical SiteAlbany, New York
North Carolina2 sites
- Kailera Clinical SiteMorehead City, North Carolina
- Kailera Clinical SiteMorrisville, North Carolina
Oklahoma1 site
- Kailera Clinical SiteNorman, Oklahoma
Rhode Island1 site
- Kailera Clinical SiteEast Greenwich, Rhode Island
South Carolina2 sites
- Kailera Clinical SiteNorth Charleston, South Carolina
- Kailera Clinical SiteSpartanburg, South Carolina
Texas2 sites
- Kailera Clinical SiteBrownsville, Texas
- Kailera Clinical SiteSan Antonio, Texas
Virginia2 sites
- Kailera Clinical SiteManassas, Virginia
- Kailera Clinical SiteRichmond, Virginia
Timeline
Started enrolling: December 30, 2025. Expected completion: April 2028. Last updated on ClinicalTrials.gov: July 22, 2026.
Official source
Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked August 21, 2026. Confirm the current status there before you contact a site:
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