A study testing whether a study medicine can help people with alcohol use disorder drink less.

Who can join: Adults 21 to 65, have alcohol use disorder, BMI 18.5+.
What you take: Check ClinicalTrials.gov for this trial's study groups and what each group receives.
How long it lasts: The full study runs about 2 years.
What you get: Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.

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Phase Phase 2Sponsor Johns Hopkins UniversityDrug PlaceboClass OtherSites 1 USEnrollment target 45

What this study is for

Primary condition: Alcohol Use Disorder.

Full scientific study title: Combination Therapy for Alcohol Use Disorder.

Who can join

Age21 to 65SexAnyBMI18.5 or higher

Adults 21 to 65, have alcohol use disorder, BMI 18.5+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

Aged 21-65 years old
Enrolled at Ashley Addiction Treatment center at least one week prior to beginning study participation.
Meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) criteria for Alcohol Use Disorder
Willing to comply with the study protocol

Key exclusion criteria

Score 9 or greater on the Clinical Institute Withdrawal Assessment for Alcohol-Revised (CIWA-Ar) at randomization
Currently pregnant, breastfeeding
Unwilling to use contraceptives (e.g., condoms and/or hormonal birth control)
Meet criteria for another substance use disorder other than AUD, Tobacco Use Disorder, or Caffeine use disorder
History of pancreatitis

Where this trial runs

This trial has 1 sites across 1 state. Site contacts are listed for reference. They are not screening through this trial right now.

Maryland1 site

Ashley Addiction Treatment
Havre de Grace, Maryland
Andrew S Huhn, Ph.D.410-550-1971ahuhn1@jhu.edu

Follow this trial

We email you if NCT07249554 changes status, adds new sites in your state, or if a similar trial opens for the same condition.

Timeline

Scheduled start: September 2026. Expected completion: September 2028. Last updated on ClinicalTrials.gov: July 13, 2026.

Official source

Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:

View on ClinicalTrials.gov →

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