A study testing whether a study medicine from Johns Hopkins University, Placebo, can help people drink less.
- Who can join
- Adults 21 to 65, have alcohol use disorder, BMI 18.5+.
- What you take
- Placebo, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
- How long it lasts
- The full study runs about 2.2 years; your own time in it is usually shorter.
- What you get
- The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.
What this study is for
Primary condition: Alcohol Use Disorder.
Full scientific study title: Combination Therapy for Alcohol Use Disorder.
Who can join
Adults 21 to 65, have alcohol use disorder, BMI 18.5+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- Aged 21-65 years old
- Enrolled at Ashley Addiction Treatment center at least one week prior to beginning study participation.
- Meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) criteria for Alcohol Use Disorder
- Willing to comply with the study protocol
Key exclusion criteria
- Score 9 or greater on the Clinical Institute Withdrawal Assessment for Alcohol-Revised (CIWA-Ar) at randomization
- Currently pregnant, breastfeeding
- Unwilling to use contraceptives (e.g., condoms and/or hormonal birth control)
- Meet criteria for another substance use disorder other than AUD, Tobacco Use Disorder, or Caffeine use disorder
- History of pancreatitis
Where this study is enrolling
This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.
Maryland1 site
- Ashley Addiction TreatmentHavre de Grace, Maryland
Timeline
Started enrolling: 2026-07. Expected completion: 2028-09. Last updated on ClinicalTrials.gov: 2026-05-12.
Official source
We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:
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