A study listed on ClinicalTrials.gov.

Recruiting now. Registry record last updated December 30, 2025.

Who can join: Adults 18+, have obesity, BMI 25+.
What you take: Check ClinicalTrials.gov for this trial's study groups and what each group receives.
How long it lasts: The full study runs about 2 years.
What you get: Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.

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Phase Not ApplicableSponsor Massachusetts General HospitalDrug investigational drugClass OtherSites 1 USEnrollment target 100

What this study is for

Primary condition: Obesity. Also studied in: Body Composition.

Full scientific study title: Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment.

Who can join

Age18 to 99SexAnyBMI25 or higher

Adults 18+, have obesity, BMI 25+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

Age ≥ 18 years old at time of signing informed consent
Started treatment with incretin therapy (liraglutide, semaglutide, tirzepatide, or retatrutide) within the past 2 months or planning to start this treatment
Able to provide informed consent

Key exclusion criteria

Current pregnancy (positive urine hCG) or plans to become pregnant in the next 6 months
BMI \<25 kg/m2 at the time of screening
Unable to participate in a regular physical exercise program
Implanted pacemaker
Any factors that, in the opinion of the principal investigator, would interfere with the safe completion of the study

Where this trial is enrolling

This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.

Massachusetts1 site

Diabetes Research Center
Boston, Massachusetts
Ben O Brenner, BS617-726-1729bbrenner1@mgb.org

Follow this trial

We email you if NCT07226947 changes status, adds new sites in your state, or if a similar trial opens for the same condition.

Timeline

Started enrolling: November 24, 2025. Expected completion: June 2027. Last updated on ClinicalTrials.gov: December 30, 2025.

Official source

Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:

View on ClinicalTrials.gov →

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John Samaras, Founder and EditorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas.
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