A study testing whether a GLP-1 medicine from Vanderbilt University Medical Center, semaglutide, works for this condition.
- Who can join
- Adults 18 to 89, have hiv, BMI 23+.
- What you take
- semaglutide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
- How long it lasts
- The full study runs about 3.8 years; your own time in it is usually shorter.
- What you get
- The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.
What this study is for
Primary condition: HIV. Also studied in: Alcohol, Smoking Cigarette, Cardiovascular Disease Prevention.
Full scientific study title: GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV.
Who can join
Adults 18 to 89, have hiv, BMI 23+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- Ages 18-89
- Prior diagnosis of HIV-1
- Affiliated with Vanderbilt Comprehensive Care Clinic
- On current ART regimen for at least 90 days prior to study entry with no missed doses for at least 7 consecutive days.
- Most recent absolute CD4 count >= 300 cells/mm3 and drawn within 12 months of study enrollment
Key exclusion criteria
- Known allergy to semaglutide
- Currently taking GLP-1 RA (in the past 3 months)
- History of diabetes defined by diagnosis in Problems List in medical record
- History of pancreatitis
- History of gastroparesis
Where this study is enrolling
This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.
Tennessee1 site
- Vanderbilt University Medical CenterNashville, Tennessee
Timeline
Started enrolling: 2026-04-17. Expected completion: 2030-01-31. Last updated on ClinicalTrials.gov: 2026-05-26.
Official source
We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:
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