Not yet recruiting · NCT07218354
A study testing whether a GLP-1 medicine from VA Office of Research and Development, semaglutide, can help people drink less.
- Who can join
- Adults 18 to 80, have alcohol use disorder, BMI 21+.
- What you take
- semaglutide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
- How long it lasts
- The full study runs about 2.8 years; your own time in it is usually shorter.
- What you get
- The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.
What this study is for
Full study title: Cessation or Reduction of Alcohol Consumption in Veterans: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial to Evaluate the Effi.
Primary condition: Alcohol Use Disorder.
Who can join, in detail
Age 18 to 80
Sex All
BMI 21+
Key inclusion criteria
- Veteran.
- WHO risk drinking level of Very High or High in the 30 days prior to screening.
- Current diagnosis of moderate or severe AUD (i.e., meeting at least 4 of 11 DSM-5 AUD criteria) based on semi-structured diagnostic exam.
- Able and willing to provide informed consent.
Key exclusion criteria
- Type 1 diabetes.
- Current serious psychiatric illness (i.e., schizophrenia, bipolar disorder, severe or psychotic major depression, borderline or antisocial personality disorder, eating disorder).
- Current DSM-5 diagnosis of a SUD (other than moderate-to-severe alcohol, any nicotine, or mild cannabis use disorders).
- At the time of randomization, moderate-to-severe alcohol withdrawal (Clinical Institute Withdrawal Assessment for Alcohol (CIWA-AR) >8).
- BMI <21 kg/m2.
Where this study is enrolling
This trial has 1 US sites across 1 states. Contact the site coordinator directly to start the screening process.
Pennsylvania
- Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PAPhiladelphia, Pennsylvania
Timeline
Started enrolling: 2026-07-01. Expected completion: 2029-05-26. Last updated on ClinicalTrials.gov: 2026-04-15.
Official source
We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:
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