A study testing whether a GLP-1 medicine from Lilly, orforglipron, can reduce bladder leaks.

Who can join

Adults 18+, women only, have stress urinary incontinence (bladder leaks), BMI 27+.

What you take

orforglipron, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.

How long it lasts

The full study runs about 2.5 years; your own time in it is usually shorter.

What you get

The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

What this study is for

Full study title: A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight.

Primary condition: Urinary Incontinence,Stress.

Who can join, in detail

Key inclusion criteria

• Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening
• Have a diagnosis of stress urinary incontinence

Key exclusion criteria

• Have had urinary incontinence surgery
• Have recently received onabotulinumtoxin A (Botox) bladder injections or currently taking medications for urinary incontinence
• Have given birth within one year of screening
• Have had a change in body weight of more than 11 pounds within 90 days prior to screening
• Have used any anti-obesity medication or alternative weight loss remedies within 180 days prior to screening

Where this study is enrolling

This trial has 21 US sites across 11 states. Contact the site coordinator directly to start the screening process.

Timeline

Started enrolling: 2025-09-30. Expected completion: 2028-03. Last updated on ClinicalTrials.gov: 2026-05-22.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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John Samaras, Founder and editorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas. About this site · LinkedIn · Contact