A study testing whether a new weekly shot from Lilly, retatrutide, can help people reduce liver fat.
Recruiting now. Registry record last updated August 21, 2026.
- Who can join
- Adults 18+, have fatty liver disease (also called MASH or NASH), BMI 25+.
- What you take
- retatrutide, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
- How long it lasts
- The full study runs about 6.8 years; your own time in it is usually shorter.
- What you get
- Many clinical trials pay for the study medication and the study visits. Some also pay for travel. Ask the study team what this one covers before you sign the consent form.
This one may not fit you. We check your age, where you live, and the rules each study sets, then show the clinical trials that do.
Check my fit →What this study is for
Primary condition: Metabolic Dysfunction-Associated Steatotic Liver Disease.
Full scientific study title: A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes).
Who can join
Age18 and upSexAnyBMI25 or higher
Adults 18+, have fatty liver disease (also called MASH or NASH), BMI 25+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- Have liver fat content ≥8%
- Have ELF score of ≥9 and ≤10.8 at screening
- Have VCTE LSM ≥10 kilopascal (kPa) and \<20 kPa at screening
Key exclusion criteria
- Have any other type of liver disease other than MASLD
- Have a body mass index (BMI) \<25 kilogram per square meter (kg/m2)
- Prior decompensated liver disease (history of esophageal/gastric varices, ascites, hepatic encephalopathy)
- Have lost more than 11 pounds within the 3 months prior to screening
- Have a hemoglobin A1c (HbA1c) greater than 10%
Where this trial is enrolling
This trial has 142 sites across 35 states. Contact a site coordinator directly to start screening.
Alabama1 site
- MFA Clinical ResearchTuscaloosa, Alabama205-331-4963
Arizona6 sites
- The Institute for Liver Health II dba Arizona Clinical Trials - ChandlerChandler, Arizona
- Spectrum Research InstituteGilbert, Arizona
- The Institute for Liver Health II dba Arizona Liver Health - PeoriaPeoria, Arizona480-470-4000
- Epic Medical Research-Sun CitySun City, Arizona
- The Institute for Liver Health II dba Arizona Clinical Trials - TucsonTucson, Arizona
- Del Sol Research Management, LLCTucson, Arizona520-257-3881
Arkansas1 site
- Arkansas Gastroenterology - North Little RockNorth Little Rock, Arkansas
California14 sites
- San Fernando Valley Health InstituteCanoga Park, California818-222-6868
- Ark Clinical Research - Fountain ValleyFountain Valley, California714-988-2021
- Fresno Clinical Research CenterFresno, California559-970-3441
- UCSD - Altman Clinical and Translational Research Institute (ACTRI)La Jolla, California858-246-2227
- Orange County Research CenterLake Forest, California714-550-9990
- Om Research LLCLancaster, California661-388-2239
- Ark Clinical ResearchLong Beach, California562-997-1000
- Los Angeles Institute for Metabolic ResearchLos Angeles, California213-373-8380
- United Medical Doctors - MurrietaMurrieta, California951-566-5229
- Knowledge Research CenterOrange, California657-247-0087
- California Liver Research CenterPasadena, California626-795-5769
- Artemis Institute for Clinical ResearchRiverside, California951-374-1190
- Medical Associates Research GroupSan Diego, California858-277-5678
- Quest Clinical ResearchSan Francisco, California415-353-0800
Colorado2 sites
- University of Colorado Anschutz Medical CampusAurora, Colorado303-724-4651
- South Denver GastroenterologyEnglewood, Colorado
Connecticut1 site
- Medical Research Center of ConnecticutHamden, Connecticut
Florida23 sites
- K2 Medical Research WINTER GARDENClermont, Florida407-426-9299
- K2 Medical Research - Daytona BeachDaytona Beach, Florida
- Care Access - Delray BeachDelray Beach, Florida401-773-7855
- AMR ClinicalDoral, Florida
- Southwest General Healthcare CenterFort Myers, Florida239-931-3368
- University of Florida College of MedicineGainesville, Florida352-273-8662
- Encore Medical ResearchHollywood, Florida954-400-1725
- Nature Coast Clinical Research - InvernessInverness, Florida352-341-2100
- Encore Borland-Groover Clinical ResearchJacksonville, Florida904-680-0871
- Health AwarenessJupiter, Florida
- K2 MEDICAL Research THE VILLAGESLady Lake, Florida352-500-5252
- Florida Research InstituteLakewood Rch, Florida941-727-7772
- Tampa Bay Medical Research - LargoLargo, Florida727-724-3316
- Evolution Clinical TrialsMiami, Florida786-706-1216
- Floridian Clinical Research, LLCMiami Lakes, Florida305-330-9977
- GI PROS ResearchNaples, Florida239-571-0899
- Charter Research - OrlandoOrlando, Florida
- Headlands Research OrlandoOrlando, Florida407-705-3471
- Progressive Medical ResearchPort Orange, Florida386-304-7070
- Covenant Metabolic Specialists - RiverviewRiverview, Florida941-894-2014
- Care Access - St. PetersburgSt. Petersburg, Florida877-791-0656
- Care Access - TamaracTamarac, Florida877-791-0656
- Covenant Metabolic Specialists, LLCUniversity Park, Florida941-894-2014
Georgia4 sites
- Southeast Clinical Research CenterDalton, Georgia706-913-1779
- Teak Research ConsultsLawrenceville, Georgia
- Gastrointestinal Specialists of GeorgiaMarietta, Georgia404-786-3100
- Rophe Adult and Pediatric Medicine/SKYCRNGUnion City, Georgia470-317-3604
Illinois1 site
- University of Chicago Medical CenterChicago, Illinois
Indiana4 sites
- Indiana University Health University HospitalIndianapolis, Indiana317-278-1652
- Gastroenterology Health PartnersNew Albany, Indiana812-206-1702
- Deaconess Clinic- GatewayNewburgh, Indiana812-490-4505
- Digestive Research Alliance of MichianaSouth Bend, Indiana574-904-9617
Iowa1 site
- Iowa Diabetes and Endocrinology Research CenterWest Des Moines, Iowa
Kansas3 sites
- AMR ClinicalEl Dorado, Kansas316-600-5127 EXT 301
- Johnson County Clinical TrialsLenexa, Kansas
- Cotton O'Neil Digestive Health CenterTopeka, Kansas785-368-0477
Kentucky1 site
- AMR ClinicalLexington, Kentucky859-264-8999
Louisiana5 sites
- Delta Research Partners of Bastrop, LLCBastrop, Louisiana318-281-6040
- Tandem Clinical ResearchMarrero, Louisiana504-934-8424
- Care Access - New IberiaNew Iberia, Louisiana813-851-0135
- Louisiana Research CenterShreveport, Louisiana318-525-3233
- Delta Research Partners of West MonroeWest Monroe, Louisiana
Maryland2 sites
- Mercy Medical Center - BaltimoreBaltimore, Maryland410-332-9356
- Capital Digestive Care - Chevy ChaseChevy Chase, Maryland301-841-6869
Massachusetts1 site
- Lucida Clinical TrialsNew Bedford, Massachusetts
Michigan3 sites
- Clinical Research Institute of Michigan, LLCClinton Township, Michigan586-598-3329
- Great Lakes Research InstituteSouthfield, Michigan248-864-5242
- Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionTroy, Michigan248-312-0025
Minnesota1 site
- MNGI Digestive HealthMinneapolis, Minnesota
Mississippi1 site
- GI Associates - GIA and Endoscopy Center - FlowoodFlowood, Mississippi601-863-0395
Missouri1 site
- AMR ClinicalKansas City, Missouri
Nevada2 sites
- Jubilee Clinical Research NV. LLCLas Vegas, Nevada702-631-5000
- Excel Clinical Research, LLCLas Vegas, Nevada702-680-1500
New Jersey5 sites
- Tandem Clinical Research - FreeholdFreehold, New Jersey
- Atlantic Health System Morristown Medical CenterMorristown, New Jersey973-971-7507
- Clinical Research of PhiladelphiaPennington, New Jersey215-676-6696
- The Cognitive and Research Center of New Jersey - RidgewoodRidgewood, New Jersey201-850-4622
- IMA Clinical Research WarrenWarren Township, New Jersey
New Mexico1 site
- Southwest Gastroenterology AssociatesAlbuquerque, New Mexico
New York5 sites
- Research Foundation of SUNY - University of BuffaloBuffalo, New York716-535-1850
- NYU Langone HealthNew York, New York646-501-2948
- IMA Clinical Research ManhattanNew York, New York
- New York Gastroenterology AssociatesNew York, New York
- Care Access - YonkersYonkers, New York
North Carolina3 sites
- Duke University - Main Hospital and ClinicsDurham, North Carolina
- Monroe Biomedical ResearchMonroe, North Carolina704-283-7359
- Carteret Medical GroupMorehead City, North Carolina252-499-8623
Ohio4 sites
- Akron Gastro ResearchAkron, Ohio
- Dayton Gastroenterology - BeavercreekBeavercreek, Ohio937-320-5050
- Clinical Research Institute of Ohio - BrooklynBrooklyn, Ohio440-363-4000
- CRIOHWestlake, Ohio440-363-4000
Pennsylvania3 sites
- US Digestive Health - FlourtownFlourtown, Pennsylvania215-664-4362
- Penn Medicine: University of Pennsylvania Health SystemPhiladelphia, Pennsylvania
- US Digestive Health - WyomissingWyomissing, Pennsylvania610-374-4401
Rhode Island1 site
- University GastroenterologyProvidence, Rhode Island
South Carolina1 site
- Columbia Digestive Health ResearchColumbia, South Carolina
Tennessee2 sites
- Galen Medical Group - Galen HepatologyChattanooga, Tennessee423-653-0842
- Gastro One (Walnut Run Road)Cordova, Tennessee
Texas29 sites
- IMA Clinical Research AustinAustin, Texas512-649-0082
- American Research CorporationAustin, Texas210-253-3426
- Pinnacle Clinical ResearchAustin, Texas512-384-1460 x3001
- Bellaire Clinical ResearchBellaire, Texas
- South Texas Research Institute - BrownsvilleBrownsville, Texas956-468-3360
- Headlands Horizons, LLC dba Headlands Research-BrownsvilleBrownsville, Texas
- Soma Clinical TrialsDenison, Texas469-819-0228
- Epic Medical Research - DeSotoDeSoto, Texas197-277-7695
- South Texas Research InstituteEdinburg, Texas956-468-3360
- Dallas Research InstituteFarmers Branch, Texas214-347-7577
- Care United Research, LLCForney, Texas972-564-0044
- GI Alliance - Fort WorthFort Worth, Texas817-612-5575
- HRI- Medical CenterHouston, Texas
- Care Access - HoustonHouston, Texas877-791-0656
- Houston Research InstituteHouston, Texas281-809-3234
- Biopharma Informatic, LLCHouston, Texas281-944-3610
- Research Physicians Network, LLCHouston, Texas281-944-3610
- Biopharma Informatic, LLCMcAllen, Texas281-944-3610
- DHR Health Institute for Research and Development (Administrative Office & Laboratory)McAllen, Texas956-362-2390
- Southern Endocrinology AssociatesMesquite, Texas214-693-0904
- HRI PasadenaPasadena, Texas832-847-1727
- American Research Corporation at Texas Liver InstituteSan Antonio, Texas210-253-3426
- Clinical Trials of Texas, LLC dba Flourish ResearchSan Antonio, Texas210-949-0122
- IMA Clinical Research San AntonioSan Antonio, Texas210-692-7157
- Consano Clinical Research, LLCShavano Park, Texas210-545-4900
- GI Alliance - SouthlakeSouthlake, Texas940-367-2316
- Houston Research Institute (HRI) - Sugar LandSugar Land, Texas
- Texas Valley Clinical ResearchWeslaco, Texas956-431-8090
- Medrasa Clinical ResearchWylie, Texas469-449-3645
Utah2 sites
- Care Access - OgdenOgden, Utah801-614-0010
- Advanced Research Institute - SandySandy City, Utah801-409-2040
Virginia4 sites
- Eximia Research - NorfolkNorfolk, Virginia
- Richmond Veterans Affairs Medical Center (Richmond VA Medical Center)Richmond, Virginia
- Virginia Commonwealth University (VCU) Medical CenterRichmond, Virginia804-828-4060
- Gastroenterology Consultants of Southwest VirginiaRoanoke, Virginia
Washington3 sites
- Washington Gastroenterology - BellevueBellevue, Washington425-454-4768
- UW Medicine Diabetes InstituteSeattle, Washington
- Washington Gastroenterology - TacomaTacoma, Washington253-272-5127
West Virginia1 site
- CAMC Health Education and Research Institute IncCharleston, West Virginia304-388-9944
Timeline
Started enrolling: October 15, 2025. Expected completion: August 2032. Last updated on ClinicalTrials.gov: August 21, 2026.
Official source
Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked August 21, 2026. Confirm the current status there before you contact a site:
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