A study of a GLP-1 and GIP medicine, tirzepatide, in adults with obesity.

Recruiting now. Registry record last updated August 27, 2026.

Who can join: Adults 18 to 50, have obesity.
What you take: Tirzepatide, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
How long it lasts: The full study runs about 2 years.
What you get: Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.

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Phase Phase 4Sponsor Pennington Biomedical Research CenterDrug tirzepatideClass GLP-1/GIPSites 2 USEnrollment target 50

What this study is for

Primary condition: Musculoskeletal Abnormalities. Also studied in: Obesity, Sarcopenic Obesity, Osteoporosis, Drug Effect.

Full scientific study title: GLP-1R Actions on Muscle and the Skeleton.

Who can join

Age18 to 50SexAny

Adults 18 to 50, have obesity. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

Subjects will have a BMI between 30 kg/m2
40 kg/m2 (inclusive)
Be between 18 and 50 years of age (inclusive).
Non-Hispanic Black males and females will be enrolled at PBRC.
Rural males and females will be enrolled at MaineHealth.

Key exclusion criteria

Menopausal females.
Subjects on systemic corticosteroids or other agents known to increase loss of muscle and bone mass.
Subjects who are on medications that increase or decrease weight status.
Subjects having contraindications to tirzepatide in the package insert.
Subjects with a history of malignancy other than non-melanoma skin cancer

Where this trial is enrolling

This trial has 2 sites across 2 states. Contact a site coordinator directly to start screening.

Find a site near you

Louisiana1 site

Pennington Biomedical Research Center
Baton Rouge, Louisiana

Maine1 site

MaineHealth Center for Clinical and Translational Science
Scarborough, Maine
Irwin Brodsky, MD, MPH207-396-7700irwin.brodsky@mainehealth.org

Follow this trial

We email you if NCT07154719 changes status, adds new sites in your state, or if a similar trial opens for the same condition.

Timeline

Started enrolling: October 9, 2025. Expected completion: May 1, 2027. Last updated on ClinicalTrials.gov: August 27, 2026.

Official source

Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:

View on ClinicalTrials.gov →

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John Samaras, Founder and EditorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas.
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