A study testing whether a GLP-1 medicine from Lilly, orforglipron, can ease joint pain.

Who can join

Adults 18+, have osteoarthritis (joint pain), BMI 27+.

What you take

orforglipron, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.

How long it lasts

The full study runs about 2.7 years; your own time in it is usually shorter.

What you get

The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

What this study is for

Full study title: A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee.

Primary condition: Osteoarthritis.

Who can join, in detail

Key inclusion criteria

• Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening
• Have tried at least once to lose weight through diet but were unsuccessful
• Have osteoarthritis of the knee and at least one of the following conditions:
• Be over 50 years old
• Have morning knee stiffness that lasts about 30 minutes

Key exclusion criteria

• Have gained or lost more than 11 pounds within 90 days prior to screening
• Have had a surgery for obesity or plan to have one in the next 18 months
• Have an active knee infection
• Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
• Have had a recent heart condition or New York Heart Association Functional Classification Class IV congestive heart failure

Where this study is enrolling

This trial has 26 US sites across 17 states. Contact the site coordinator directly to start the screening process.

Timeline

Started enrolling: 2025-09-15. Expected completion: 2028-05. Last updated on ClinicalTrials.gov: 2026-05-22.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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John Samaras, Founder and editorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas. About this site · LinkedIn · Contact