A study testing whether a long-used diabetes pill, metformin, affects healthy aging.

Recruiting now. Registry record last updated July 30, 2025.

Who can join: Adults 40 to 85, are joining a healthy-aging study, BMI 22+.
What you take: Metformin, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
How long it lasts: The study runs about 8 months.
What you get: Many clinical trials pay for the study medication and the study visits. Some also pay for travel. Ask the study team what this one covers before you sign the consent form.

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Phase Phase 2Sponsor AgelessRxDrug MetforminClass OtherSites 1 USEnrollment target 150

What this study is for

Primary condition: Longevity. Also studied in: GLP-1, Geroscience, Aging.

Full scientific study title: Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation.

Who can join

Age40 to 85SexAnyBMI22 or higher

Adults 40 to 85, are joining a healthy-aging study, BMI 22+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

Existing AgelessRx patient
Adults (40 - 85 years of age)
Any sex
Any ethnicity
BMI ≥ 22 kg/m\^2

Key exclusion criteria

Individuals who are denied a longevity product by the AgelessRx medical team will not be asked to participate in any product specific test(s) or questionnaire(s)
History of bariatric surgery
Use of weight-loss medications other than GLP-1s within the past 6 months
Age \<40 years
Contraindications to naltrexone, metformin, or rapamycin

Where this trial is enrolling

This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.

Illinois1 site

AgelessRx
Chicago, Illinois
Ashley Valdes, BS650-272-3169avaldes@agelessrx.com

Follow this trial

We email you if NCT07092618 changes status, adds new sites in your state, or if a similar trial opens for the same condition. No spam, opt out any time.

Timeline

Started enrolling: December 17, 2024. Expected completion: August 2025. Last updated on ClinicalTrials.gov: July 30, 2025.

Official source

Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked August 21, 2026. Confirm the current status there before you contact a site:

View on ClinicalTrials.gov →

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John Samaras, Founder and EditorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas.
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