A study testing whether a GLP-1 medicine, semaglutide, can help people lose weight.
Recruiting now. Registry record last updated July 10, 2026.
- Who can join
- Adults 50 to 75, have obesity, BMI 30+.
- What you take
- Semaglutide, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
- How long it lasts
- The full study runs about 4 years.
- What you get
- Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.
What this study is for
Primary condition: Obesity. Also studied in: Skeletal Muscle, Brain Connectivity.
Full scientific study title: Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity.
Who can join
Adults 50 to 75, have obesity, BMI 30+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- i) obesity (Body Mass Index ≥ 30 kg/m2)
- ii) decreased physical function (Modified Physical Performance Test score 17 to 31)
- iii) approval of their primary physician to participate in this study.
Key exclusion criteria
- i) unstable weight (\>4% change during the last 2 months before entering the study)
- ii) ≥150 min per week of structured exercise (e.g., jogging, activities that cause heavy breathing and sweating)
- iii) diabetes
- iv) significant cardiopulmonary disease (heart failure, angina, uncontrolled hypertension, chronic obstructive pulmonary disease) or other organ dysfunction (e.g., renal insufficiency \[eGFR \<30 mL/min/1.73 m2\])
- v) therapy with a GLP-1 or other weight loss medications
Where this trial is enrolling
This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.
Missouri1 site
- Washington University School of MedicineSt Louis, MissouriCoordinator314-273-1879
Timeline
Started enrolling: August 11, 2025. Expected completion: August 1, 2029. Last updated on ClinicalTrials.gov: July 10, 2026.
Official source
Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:
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