Not yet recruiting · NCT07021937

A study testing whether a GLP-1 medicine from University of Colorado, Denver, semaglutide, can help with weight.

Who can join: Ages 12 to 45, have obesity, BMI 35+.
What you take: semaglutide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
How long it lasts: The full study runs about 4.9 years; your own time in it is usually shorter.
What you get: The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

Phase Phase 3Sponsor University of Colorado, DenverDrug semaglutideClass GLP-1 RASites 1 USEnrollment target 120

What this study is for

Full study title: Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity.

Primary condition: Obesity/Therapy.

Who can join, in detail

Age 12 to 45

Sex All

BMI 35+

Key inclusion criteria

English-speaking
male or female (sex assigned at birth)
12-18 y/o with obesity (BMI>120% of the 95th %ile)
30-45 y/o with obesity (BMI>35 kg/m2)

Key exclusion criteria

treated with glucagon-like peptide-1 (GLP-1) agonists (e.g., exenatide, liraglutide, semaglutide, tirzepatide) for weight management in the prior 3 months
currently taking anti-psychotic medications (anti-depressants accepted)
diagnosis of type 2 diabetes
current or lifetime anorexia nervosa or current bulimia nervosa
head injury resulting in loss of consciousness >30min

Where this study is enrolling

This trial has 1 US sites across 1 states. Contact the site coordinator directly to start the screening process.

Colorado

University of Colorado Anschutz Medical Campus
Aurora, Colorado
Allison Shapiro, PhD, MPH3037243733allison.shapiro@cuanschutz.edu

Follow this trial

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Timeline

Started enrolling: 2026-05-01. Expected completion: 2031-04-30. Last updated on ClinicalTrials.gov: 2025-06-15.

Official source

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