A study testing whether a GLP-1 medicine from Mayo Clinic, liraglutide, can lower blood sugar and help with weight.

Who can join: Adults 25 to 70, have type 1 diabetes.
What you take: liraglutide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
How long it lasts: The full study runs about 3.4 years; your own time in it is usually shorter.
What you get: The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

Phase Phase 2Sponsor Mayo ClinicDrug liraglutideClass GLP-1 RASites 1 USEnrollment target 60

What this study is for

Primary condition: Type 1 Diabetes. Also studied in: Type 2 Diabetes.

Full scientific study title: The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes.

Who can join

Age25 to 70SexAny

Adults 25 to 70, have type 1 diabetes. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

Type 1 or type 2 diabetes treated with insulin

Key exclusion criteria

Age < 25 or > 70 years.
HbA1c > 10.0%
For female subjects: positive pregnancy test at the time of enrollment or study
History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
Prior use of GLP-1 receptor agonists in the previous year.

Where this study is enrolling

This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.

Minnesota1 site

Mayo Clinic in Rochester
Rochester, Minnesota
Amy O'Byrne507-255-8547OByrne.Amy14@mayo.edu

Follow this trial

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Timeline

Started enrolling: 2025-10-03. Expected completion: 2029-03-31. Last updated on ClinicalTrials.gov: 2025-10-14.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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John Samaras, Founder and EditorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas.
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