A study testing whether a GLP-1 medicine from University of Colorado, Denver, semaglutide, works for this condition.
- Who can join
- Adults 45 to 55, women only, have menopause.
- What you take
- semaglutide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
- How long it lasts
- The full study runs about 4.6 years; your own time in it is usually shorter.
- What you get
- The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.
What this study is for
Primary condition: Menopause. Also studied in: Menopause Hot Flashes, Menopause Related Conditions, Cardiovascular.
Full scientific study title: Focusing on the Menopausal Transition to Improve Mid-Life Women's Health.
Who can join
Adults 45 to 55, women only, have menopause. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- aged 45-55
- In the late menopausal transition, defined as 60 days of amenorrhea but less than 365 days of amenorrhea18
- No current use of hormone therapy or hormonal contraception
- Presence of a uterus and at least one ovary in order to track menstrual patterns
- Have a smartphone and broadband access adequate to accept telehealth appointments
Key exclusion criteria
- Lack of broadband access (activity and survey data will be collected electronically whenever possible and some visits will be via telehealth)
- Lack of regular menstrual periods in mid-reproductive life (ages 25-38) when not on hormones or not pregnant.
- Pregnancy or actively trying to get pregnant
- Inability to adhere to study protocol schedule
- Untreated alcoholism
Where this study is enrolling
This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.
Colorado1 site
- University of Colorado-School of MedicineAurora, Colorado
Timeline
Started enrolling: 2026-03-01. Expected completion: 2030-10-01. Last updated on ClinicalTrials.gov: 2026-04-30.
Official source
We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:
Other GLP-1 clinical trials
Back to the full directory → or take the matching quiz if you want clinical trials filtered to your conditions and location.
