A study testing whether a study medicine can help people with prediabetes lower blood sugar.

Recruiting now. Registry record last updated December 15, 2025.

Who can join: Adults 25 to 70, have prediabetes.
What you take: Check ClinicalTrials.gov for this trial's study groups and what each group receives.
How long it lasts: The full study runs about 2 years.
What you get: Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.

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Phase Phase 2Sponsor Mayo ClinicDrug investigational drugClass OtherSites 1 USEnrollment target 60

What this study is for

Primary condition: PreDiabetes.

Full scientific study title: The Role of Islet GLP-1 in the Pathogenesis of Prediabetes.

Who can join

Age25 to 70SexAny

Adults 25 to 70, have prediabetes. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

People with stable weight and no history of diabetes.
Fasting glucose \< 126 mg/dL
2hr glucose after 75g OGTT \< 200 mg/dL

Key exclusion criteria

Age \< 25 or \> 70 years (to avoid studying subjects who could have latent type 1 diabetes, or the effects of age extremes in subjects with normal or impaired fasting glucose).
HbA1c \> 6.5%
Use of any glucose-lowering agents including metformin or sulfonylureas.
For female subjects: positive pregnancy test at the time of enrollment or study
History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.

Where this trial is enrolling

This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.

Minnesota1 site

Mayo Clinic in Rochester
Rochester, Minnesota
Amy O'Byrne507-255-8547OByrne.Amy14@mayo.edu

Follow this trial

We email you if NCT06967558 changes status, adds new sites in your state, or if a similar trial opens for the same condition.

Timeline

Started enrolling: November 1, 2025. Expected completion: March 31, 2028. Last updated on ClinicalTrials.gov: December 15, 2025.

Official source

Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:

View on ClinicalTrials.gov →

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John Samaras, Founder and EditorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas.
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