A study testing whether a GLP-1 medicine, semaglutide, can help people lose weight.
Recruiting now. Registry record last updated July 21, 2026.
- Who can join
- Children and teens 12 to 17, have obesity or are overweight.
- What you take
- Semaglutide, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
- How long it lasts
- The full study runs about 3 years.
- What you get
- Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.
What this study is for
Primary condition: Obesity and Overweight. Also studied in: Obese Adolescents, Weight Management, Weight Loss, Cardiovascular Disease Risk Factor.
Full scientific study title: Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity.
Who can join
Children and teens 12 to 17, have obesity or are overweight. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- Patient seen at University of Kentucky Pediatric High BMI Clinic
- Diagnosis of Obesity Class 2 or 3
- Meeting the clinical criteria for the medical intervention with semaglutide for weight loss
Key exclusion criteria
- Any current prescribed anti-obesity medications (AOM) such as Orlistat, Phentermine, Qsymia (Phentermine/Topiramate), Liraglutide, Semaglutide, and Setmelanotide
- Any current prescribed anti-hypertensive medications
- Any specific end-organ acute concerns (kidney disease, liver disease, congenital disease).
- Any active infections at enrollment.
- Any systemic steroid use longer than 3 month use or within the last month before enrollment (not including inhaled, ophthalmic, intranasal, and topical).
Where this trial is enrolling
This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.
Kentucky1 site
- University of KentuckyLexington, Kentucky
Timeline
Started enrolling: June 12, 2025. Expected completion: July 2028. Last updated on ClinicalTrials.gov: July 21, 2026.
Official source
Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:
Other GLP-1 clinical trials
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