A study testing whether an investigational Lilly medicine (LY3457263) from Lilly can lower blood sugar and help with weight.

Who can join

Adults 18 to 75, have type 2 diabetes, BMI 27+.

What you take

LY3457263, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.

How long it lasts

The full study runs about 1.8 years; your own time in it is usually shorter.

What you get

The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

What this study is for

Full study title: A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide.

Primary condition: Type 2 Diabetes.

Who can join, in detail

Key inclusion criteria

• Have type 2 diabetes
• Have HbA1c >=7.5% to <=10.5% at screening
• Have a body mass index (BMI) of >=27 kilograms per square meter (kg/m2) at screening
• Have had a stable body weight for the three months prior to screening
• On stable treatment dose of one of the following incretins for at least three months prior to screening:

Key exclusion criteria

• Have type 1 diabetes, latent autoimmune diabetes, or history of ketoacidosis or hyperosmolar coma
• Have a prior or planned surgical treatment for obesity
• Have any of the following cardiovascular conditions within three months prior to screening:
• acute myocardial infarction
• cerebrovascular accident (stroke)

Where this study is enrolling

This trial has 25 US sites across 14 states. Contact the site coordinator directly to start the screening process.

Timeline

Started enrolling: 2025-03-28. Expected completion: 2027-01. Last updated on ClinicalTrials.gov: 2026-05-22.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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