A study testing whether a new weekly shot from The Cleveland Clinic, tirzepatide, works for this condition.
- Who can join
- Adults 18 to 80, have atrial fibrillation, BMI 27+.
- What you take
- tirzepatide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
- How long it lasts
- The full study runs about 2.2 years; your own time in it is usually shorter.
- What you get
- The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.
What this study is for
Primary condition: Atrial Fibrillation. Also studied in: Obesity.
Full scientific study title: TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation.
Who can join
Adults 18 to 80, have atrial fibrillation, BMI 27+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- Sinus rhythm at randomization
- Sustained normal sinus rhythm (or)
- Normal sinus rhythm at office visit
- Age >=18 to <=80 years old
- BMI >= 27 and <=60 kg/m2
Key exclusion criteria
- AFIB ablation within the last 6 months
- Planned ablation prior to 3 months post randomization
- Significant cardiac valvular disease with planned cardiac valve intervention/surgery in the next 12 months
- Severe uncompensated cardiopulmonary disease
- New York Heart Association Class III or IV
Where this study is enrolling
This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.
Ohio1 site
- Cleveland ClinicCleveland, Ohio
Timeline
Started enrolling: 2025-04-08. Expected completion: 2027-06-01. Last updated on ClinicalTrials.gov: 2026-01-13.
Official source
We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:
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