A study of a GLP-1 medicine, semaglutide, in people with cocaine use disorder.
Recruiting now. Registry record last updated August 24, 2025.
- Who can join
- Adults 18 to 65, have cocaine use disorder, BMI 20+.
- What you take
- Semaglutide, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
- How long it lasts
- The full study runs about 2 years.
- What you get
- Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.
What this study is for
Primary condition: Cocaine Use Disorder. Also studied in: HIV.
Full scientific study title: Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV.
Who can join
Adults 18 to 65, have cocaine use disorder, BMI 20+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- At least 18 years old
- Meet criteria for CUD according to the Diagnostic and Statistical Manual Version 5
- Used cocaine at least 7 out of the past 14 days
- Body Mass Index between 20 - 50 kg/m2
- English proficiency
Key exclusion criteria
- Triglycerides \> 500 mg/dL
- History of gall bladder disease
- Personal or family history of medullary thyroid carcinoma, or patients with a history of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- History of diabetic retinopathy
- Being prescribed glucose-lowering medications
Where this trial is enrolling
This trial has 2 sites across 2 states. Contact a site coordinator directly to start screening.
District of Columbia1 site
- Institute of Human Virology at the University of Maryland School of MedicineWashington D.C., District of Columbia
Maryland1 site
- Institute of Human Virology at the University of Maryland School of MedicineBaltimore, Maryland
Timeline
Started enrolling: August 7, 2025. Expected completion: March 2027. Last updated on ClinicalTrials.gov: August 24, 2025.
Official source
Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:
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