A study testing whether a long-used diabetes pill, metformin, can help people with prediabetes lower blood sugar.

Who can join: Adults 18 to 75, have type 2 diabetes, BMI 22+.
What you take: Metformin, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
How long it lasts: The full study runs about 3 years.
What you get: Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.

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Phase Phase 4Sponsor Stanford UniversityDrug MetforminClass OtherSites 1 USEnrollment target 200

What this study is for

Primary condition: Prediabetes / Type 2 Diabetes.

Full scientific study title: Heterogeneity of Diabetes: Integrated Muli-Omics to Identify Physiologic Subphenotypes and Evaluate Targeted Prevention.

Who can join

Age18 to 75SexAnyBMI22 to 45

Adults 18 to 75, have type 2 diabetes, BMI 22+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

BMI ≥23 (≥22 in Asians) kg/m2 but \< 45 kg/m2
HbA1c 5.7-8.0% while not on antihyperglycemic medications

Key exclusion criteria

Recent (\<6mos) CVD event
active malignancy, kidney/liver disease pregnancy/lactation, chronic inflammatory disease, eating disorder, bariatric surgery
history of acute pancreatitis
family or personal history of medullary thyroid cancer
current use of antihyperglycemic, diabetogenic, or weight loss medications (washout allowed if approved by primary physician)

Where this trial runs

This trial has 1 sites across 1 state. Site contacts are listed for reference. They are not screening through this trial right now.

California1 site

Stanford University
Stanford, California
Alina Choi, BSlinachoi@stanford.edu

Follow this trial

We email you if NCT06682351 changes status, adds new sites in your state, or if a similar trial opens for the same condition.

Timeline

Scheduled start: November 2024. Expected completion: December 2027. Last updated on ClinicalTrials.gov: November 12, 2024.

Official source

Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:

View on ClinicalTrials.gov →

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