A study testing whether a GLP-1 medicine from Lilly, orforglipron, can help people lose weight.
Recruiting now. Registry record last updated July 20, 2026.
- Who can join
- Children and teens 6 to 17, have obesity.
- What you take
- orforglipron, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
- How long it lasts
- The full study runs about 2.3 years; your own time in it is usually shorter.
- What you get
- Many clinical trials pay for the study medication and the study visits. Some also pay for travel. Ask the study team what this one covers before you sign the consent form.
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Check my fit →What this study is for
Primary condition: Obesity. Also studied in: Overweight.
Full scientific study title: A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040).
Who can join
Age6 to 17SexAny
Children and teens 6 to 17, have obesity. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- Have a history of at least 1 unsuccessful effort to lose sufficient body weight after participation in a structured lifestyle modification program (diet and exercise counseling for at least 3 months) prior to screening.
- Obesity as defined by BMI equal to or above the 95th percentile for age and sex (on age- and gender-specific growth chart \[CDC-NCHS, 2022\]); OR
- Applies to participant age between 12 and \<18 years old. Overweight as defined by BMI equal to or above the 85th percentile but less than the 95th percentile for age and sex, on age- and sex-specific growth chart (CDC-NCHS, 2022), and at least 1 weight-related comorbidity,
- hypertension
- type 2 diabetes (T2D)
Key exclusion criteria
- Have undergone or plan to undergo weight reduction procedure during the study, such as, but not limited to:
- gastric bypass
- sleeve gastrectomy
- restrictive bariatric surgery, such as Lap-Band® gastric banding, or
- any other procedure intended to result in weight reduction.
Where this trial is enrolling
This trial has 51 sites across 29 states. Contact a site coordinator directly to start screening.
Arizona1 site
- University of ArizonaTucson, Arizona
California5 sites
- Loma Linda University School of MedicineLoma Linda, California
- Childrens Hospital of Los AngelesLos Angeles, California
- UCLA Mattel Children's HospitalLos Angeles, California
- Children's Hospital of Orange County - OrangeOrange, California
- Carey Chronis MD Pediatric, Infant and Adolescent MedicineVentura, California805-642-4704
Colorado1 site
- Children's Hospital ColoradoColorado Springs, Colorado
Connecticut2 sites
- Yale School of Medicine - Yale Diabetes Center (YDC)) TrialsNew Haven, Connecticutania.jastreboff@yale.edu
- Stamford Therapeutics ConsortiumStamford, Connecticut727-544-4842
Florida4 sites
- William A. Shands Hospital at the University of FloridaGainesville, Florida
- Florida Hospital- Center for Pediatric ResearchOrlando, Florida
- Nemours Children's HealthOrlando, Florida
- All Childrens HospitalSt. Petersburg, Florida
Georgia1 site
- Children's Healthcare of Atlanta - Center for Advanced PediatricsAtlanta, Georgia404-712-4731
Illinois2 sites
- Ann and Robert Lurie Children's Hospital of ChicagoChicago, Illinois312-503-1499
- University of Illinois at ChicagoChicago, Illinois
Indiana1 site
- Riley Hospital for ChildrenIndianapolis, Indiana
Kentucky1 site
- Norton Children's EndocrinologyLouisville, Kentucky
Louisiana1 site
- Velocity Clinical ResearchLafayette, Louisiana337-519-4742
Maryland1 site
- Johns Hopkins Children's CenterBaltimore, Maryland
Massachusetts1 site
- Boston Children's HospitalBoston, Massachusetts
Michigan1 site
- Helen Devos Childrens' Hospital - PINGrand Rapids, Michigan
Minnesota3 sites
- University of Minnesota Masonic Children's HospitalMinneapolis, Minnesota
- Mayo Clinic - PINRochester, Minnesota
- Children's Minnesota Pediatric Endocrinology Clinic & McNeeley Diabetes CenterSaint Paul, Minnesota
Mississippi1 site
- Dynamed Clinical Research, LP d/b/a DM Clinical ResearchGulfport, Mississippi228-206-1283
Missouri1 site
- Sundance Clinical ResearchSt Louis, Missouri314-567-3377
Nebraska2 sites
- Omaha Childrens HospitalOmaha, Nebraska
- Velocity Clinical ResearchOmaha, Nebraska402-933-6500
New Jersey1 site
- Hackensack University Medical CenterHackensack, New Jersey
New York1 site
- UBMD PediatricsBuffalo, New York
North Carolina3 sites
- UNC Children's HospitalChapel Hill, North Carolina
- Duke Children's Primary CareDurham, North Carolina
- Lucas Research, IncMorehead City, North Carolina252-222-5700
Ohio2 sites
- Cleveland ClinicCleveland, Ohio
- Nationwide Children's HospitalColumbus, Ohio
Oklahoma1 site
- University of Oklahoma Health Sciences CenterOklahoma City, Oklahoma
Pennsylvania1 site
- UPMC Children's Hospital of PittsburghPittsburgh, Pennsylvania412-692-6935
South Carolina2 sites
- Coastal Pediatric AssociatesCharleston, South Carolina
- Medical University of South Carolina Children Hospital - PINCharleston, South Carolina
Tennessee1 site
- Vanderbilt Health One Hundred OaksNashville, Tennessee615-322-6000
Texas6 sites
- Dell Children's Medical Center - PINAustin, Texas
- Driscoll Children's HospitalCorpus Christi, Texas
- McGovern Medical SchoolHouston, Texas
- Dynamed Clinical Research, LP d/b/a DM Clinical ResearchHouston, Texas281-517-0550
- La Providence Pediatrics Clinic - Chemidox Clinical TrialsHouston, Texas833-324-3643
- Martin Diagnostic ClinicTomball, Texas281-517-0550
Utah1 site
- Velocity Clinical Research, Salt Lake CityWest Jordan, Utah801-542-8190
Virginia1 site
- VCU Health - Center for Endocrinology Diabetes and MetabolismRichmond, Virginia
Washington2 sites
- Seattle Children's Research Institute - Hughes Building - PINSeattle, Washington
- MultiCare Health System - Mary Bridge Children's Health CenterTacoma, Washington
Timeline
Started enrolling: November 18, 2024. Expected completion: March 2027. Last updated on ClinicalTrials.gov: July 20, 2026.
Official source
Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked August 21, 2026. Confirm the current status there before you contact a site:
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