A study testing whether a GLP-1 and GIP medicine, tirzepatide, can help people with obesity lose weight.

Recruiting now. Registry record last updated July 15, 2026.

Who can join: Ages 12 to 24, have obesity.
What you take: Tirzepatide, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
How long it lasts: The full study runs about 3 years.
What you get: Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.

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Phase Phase 1Sponsor University of Colorado, DenverDrug tirzepatideClass GLP-1/GIPSites 1 USEnrollment target 40

What this study is for

Primary condition: Obesity. Also studied in: Adolescent Obesity, Body-Weight Trajectory, Weight Loss Trajectory, Bariatric Surgery, Anti-obesity Agents.

Full scientific study title: Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents.

Who can join

Age12 to 24SexAnyBMIany to 30

Ages 12 to 24, have obesity. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

Signed and dated informed consent form
Willingness to comply with all study procedures and availability for the duration of the study
Male or female biological sex, age 12 through 24 years
In the preoperative pathway for vertical sleeve gastrectomy

Key exclusion criteria

Planned Roux-en-Y gastric bypass
Hypothalamic obesity
Type 2 Diabetes
Current use of oral glucocorticoids (i.e. within 10 days of baseline visit)
Current use of insulin

Where this trial is enrolling

This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.

Colorado1 site

Childrens Hospital Colorado
Aurora, Colorado
Jaime Moore, MD MPH303-724-8419jaime.moore@cuanschutz.edu

Follow this trial

We email you if NCT06575738 changes status, adds new sites in your state, or if a similar trial opens for the same condition.

Timeline

Started enrolling: October 11, 2024. Expected completion: October 1, 2027. Last updated on ClinicalTrials.gov: July 15, 2026.

Official source

Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:

View on ClinicalTrials.gov →

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John Samaras, Founder and EditorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas.
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