A study testing whether a GLP-1 medicine, semaglutide, can help people with prediabetes lower blood sugar and lose weight.

Recruiting now. Registry record last updated November 12, 2025.

Who can join: Adults 18+, have prediabetes, BMI 25+.
What you take: Semaglutide, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
How long it lasts: The full study runs about 3 years.
What you get: Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.

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Phase Phase 1Sponsor The University of Texas Health Science Center at San AntonioDrug semaglutideClass GLP-1 RASites 1 USEnrollment target 64

What this study is for

Primary condition: Pre-Diabetes. Also studied in: Weight, Body, Cardiovascular Diseases.

Full scientific study title: Prevention of Progression of Prediabetes, Obesity and CV Risk.

Who can join

Age18 and upSexAnyBMI25 to 40

Adults 18+, have prediabetes, BMI 25+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

Patients will have an established diagnosis of pre-Diabetes Mellitus (DM) before the screening visit, documented by an acceptable modality in the last 6 months.
Age ≥ 18 years old
Body Mass Index (BMI)=25-40 kg/m2
Glycated Hemoglobin (HbA1c) = 5.7-6.4%
Blood Pressure (BP) \<160/100

Key exclusion criteria

Patients currently on one of the selected therapies
Extended diagnoses with Type 2 Diabetes
Pregnancy, lactation, women of childbearing age (WOCBA) unwilling to use contraception
Known allergy/sensitivity to study drugs or their ingredients
Major oncologic diagnosis in the last 5 years

Where this trial is enrolling

This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.

Texas1 site

University of Texas Health Science Center at San Antonio
San Antonio, Texas
Carolina Solis-Herrera, MD210-567-4900solisherrera@uthscsa.edu

Follow this trial

We email you if NCT06446531 changes status, adds new sites in your state, or if a similar trial opens for the same condition.

Timeline

Started enrolling: September 11, 2024. Expected completion: July 2027. Last updated on ClinicalTrials.gov: November 12, 2025.

Official source

Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:

View on ClinicalTrials.gov →

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John Samaras, Founder and EditorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas.
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