Enrolling now · NCT06439277

A study testing whether a new weekly shot from Lilly, tirzepatide, can help with weight.

Who can join: Children and teens 12 to 17, have obesity.
What you take: tirzepatide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
How long it lasts: The full study runs about 6.5 years; your own time in it is usually shorter.
What you get: The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

Phase Phase 3Sponsor Eli Lilly and CompanyDrug tirzepatideClass GLP-1/GIPSites 15 USEnrollment target 300

What this study is for

Full study title: A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2).

Primary condition: Obesity. Also studied in: Weight Gain.

Who can join, in detail

Age 12 to 17

Sex All

Key inclusion criteria

Have body mass index (BMI) equal to or above the 95th percentile for age and sex (on age and gender-specific growth chart for diagnosis of obesity) with at least 2 of the following predefined weight-related comorbidities: hypertension, prediabetes and hypertriglyceridemia.
Have history of at least 1 self-reported unsuccessful dietary effort to lose weight.
Are capable of giving signed informed consent by a legal representative or assent by a study participant (when applicable).

Key exclusion criteria

Have undergone or plan to undergo a weight reduction procedure during the study, such as, but not limited to
gastric bypass
sleeve gastrectomy
restrictive bariatric surgery, such as Lap-Band gastric banding, or
any other procedure intended to result in weight reduction.

Where this study is enrolling

This trial has 15 US sites across 9 states. Contact the site coordinator directly to start the screening process.

California

Children's Hospital Los Angeles
Los Angeles, California
Sutter Valley Medical Foundation (SVMF) Pediatric Endocrinology
Sacramento, California

Delaware

Nemours Children's Health - Delaware
Wilmington, Delaware

Georgia

CenExel iResearch, LLC
Decatur, Georgia
404-537-1281

Idaho

Medical Research Partners
Ammon, Idaho

Illinois

Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois

Indiana

Indiana University Health University Hospital
Indianapolis, Indiana

New York

UBMD Pediatrics
Buffalo, New York
SUNY Upstate Medical University
Syracuse, New York

Texas

Driscoll Children's Hospital
Corpus Christi, Texas
Epic Medical Research - DeSoto
DeSoto, Texas
Valley Institute of Research - Fort Worth
Fort Worth, Texas
Consano Clinical Research, LLC
Shavano Park, Texas
Texas Valley Clinical Research
Weslaco, Texas

Utah

Alliance for Multispecialty Research, LLC
Layton, Utah

Follow this trial

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Timeline

Started enrolling: 2024-06-03. Expected completion: 2030-12. Last updated on ClinicalTrials.gov: 2026-05-19.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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