A study testing whether a new weekly shot, tirzepatide, can help people lower blood sugar.
Recruiting now. Registry record last updated March 10, 2026.
- Who can join
- Adults 18 to 75, have type 2 diabetes.
- What you take
- tirzepatide, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
- How long it lasts
- The full study runs about 4.6 years; your own time in it is usually shorter.
- What you get
- Many clinical trials pay for the study medication and the study visits. Some also pay for travel. Ask the study team what this one covers before you sign the consent form.
What this study is for
Primary condition: Type 2 Diabetes (Adult Onset).
Full scientific study title: Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset Diabetes.
Who can join
Adults 18 to 75, have type 2 diabetes. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- Ability of subject to understand and the willingness to sign a written informed consent document.
- Males and females; Age 18-75 years
- Recently (within 5 years) diagnosed Type 2 Diabetes Mellitus (T2DM) patients
- Drug naïve or receiving metformin monotherapy
- HbA1c \>6.5% (no limit on upper HbA1c value);
Key exclusion criteria
- positive anti-GAD (antibodies to glutamic acid decarboxylase)
- pregnancy or plan of becoming pregnant
- evidence of proliferative diabetic retinopathy,
- plasma creatinine \>1.4 females or \>1.5 males;
- presence of congestive heart failure (CHF);
Where this trial is enrolling
This trial has 2 sites across 1 state. Contact a site coordinator directly to start screening.
Texas2 sites
- University Health System Texas Diabetic InstituteSan Antonio, Texas
- UT Health Science CenterSan Antonio, Texas
Timeline
Started enrolling: November 7, 2024. Expected completion: June 30, 2029. Last updated on ClinicalTrials.gov: March 10, 2026.
Official source
Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked August 21, 2026. Confirm the current status there before you contact a site:
Other GLP-1 clinical trials
Back to the full directory → or take the matching quiz if you want clinical trials filtered to your conditions and location.
