A study testing whether a new weekly shot from Lilly, tirzepatide, can help with weight.

Who can join

Adults 18 to 75, have obesity, BMI 27+.

What you take

tirzepatide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.

How long it lasts

The full study runs about 4.3 years; your own time in it is usually shorter.

What you get

The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

What this study is for

Full study title: A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight.

Primary condition: Obesity. Also studied in: Overweight.

Who can join, in detail

Key inclusion criteria

• Have a body mass index (BMI)
• >=30 kilogram/square meter (kg/m²), or
• >=27 kg/m² and <30 kg/m², or with at least 1 weight-related comorbidity
• Have had a stable body weight for the 3 months prior to randomization (<5%) body weight gain and/or loss.

Key exclusion criteria

• Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening.
• Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
• Have poorly controlled hypertension.
• Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
• Have any of the following cardiovascular conditions within 3 months prior to screening:

Where this study is enrolling

This trial has 49 US sites across 22 states. Contact the site coordinator directly to start the screening process.

Timeline

Started enrolling: 2023-11-17. Expected completion: 2028-02. Last updated on ClinicalTrials.gov: 2026-05-14.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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