Home›Clinical trials›A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

A study testing whether an investigational medicine from Lilly, LY3305677, can help people lose weight.

Recruiting now. Registry record last updated August 6, 2026.

Who can join
Adults 18 to 75, have obesity, BMI 27+.
What you take
LY3305677, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
How long it lasts
The full study runs about 4.3 years; your own time in it is usually shorter.
What you get
Many clinical trials pay for the study medication and the study visits. Some also pay for travel. Ask the study team what this one covers before you sign the consent form.
This one may not fit you. We check your age, where you live, and the rules each study sets, then show the clinical trials that do.
Check my fit →
Phase Phase 2Sponsor Eli Lilly and CompanyDrug LY3305677Class OtherSites 50 USEnrollment target 1,481

What this study is for

Primary condition: Obesity. Also studied in: Overweight.

Full scientific study title: A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight.

Who can join

Age18 to 75SexAnyBMI27 or higher

Adults 18 to 75, have obesity, BMI 27+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

  • Have a body mass index (BMI)
  • ≥30 kilogram/square meter (kg/m²), or
  • ≥27 kg/m² and \<30 kg/m², or with at least 1 weight-related comorbidity
  • Have had a stable body weight for the 3 months prior to randomization (\<5%) body weight gain and/or loss.

Key exclusion criteria

  • Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening.
  • Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
  • Have poorly controlled hypertension.
  • Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
  • Have any of the following cardiovascular conditions within 3 months prior to screening:

Where this trial is enrolling

This trial has 50 sites across 22 states. Contact a site coordinator directly to start screening.

Arizona4 sites
  • The Institute for Liver Health II dba Arizona Clinical Trials - Mesa
    Chandler, Arizona
  • HOPE Research Institute
    Phoenix, Arizona
  • Headlands Research - Scottsdale
    Scottsdale, Arizona
    480-725-8708
  • The Institute for Liver Health II dba Arizona Liver Health-Tucson
    Tucson, Arizona
    480-470-4000
California4 sites
  • NorCal Medical Research, Inc
    Greenbrae, California
    415-461-1585
  • Velocity Clinical Research, Huntington Park
    Huntington Park, California
    323-588-1990
  • Peninsula Research Associates
    Rolling Hills Estates, California
    310-265-1623
  • Diablo Clinical Research, Inc.
    Walnut Creek, California
    925-930-7267
Connecticut1 site
  • Stamford Therapeutics Consortium
    Stamford, Connecticut
Florida6 sites
  • Northeast Research Institute (NERI)
    Fleming Island, Florida
  • New Horizon Research Center
    Miami, Florida
    305-226-3933
  • Indago Research & Health Center, Inc
    Miami Lakes, Florida
    305-825-6588
  • Suncoast Clinical Research, Inc.
    New Port Richey, Florida
    727-849-4131
  • Charter Research - Winter Park
    Orlando, Florida
    407-337-3000
  • Charter Research - Lady Lake
    The Villages, Florida
    352-441-2000
Hawaii1 site
  • Pacific Diabetes & Endocrine Center
    Honolulu, Hawaii
Idaho1 site
  • Medical Research Partners
    Ammon, Idaho
    208-681-9070
Illinois3 sites
  • Great Lakes Clinical Trials - Ravenswood
    Chicago, Illinois
  • Great Lakes Clinical Trials - Ravenswood
    Chicago, Illinois
    773-275-3500 Ext 162
  • NorthShore University Health System
    Skokie, Illinois
Iowa1 site
  • Iowa Diabetes and Endocrinology Research Center
    West Des Moines, Iowa
    515-329-6800
Kansas1 site
  • Cotton O'Neil Diabetes & Endocrinology
    Topeka, Kansas
    785-354-9591
Kentucky1 site
  • Monroe Biomedical Research - Louisville
    Louisville, Kentucky
    502-515-5672
Massachusetts2 sites
  • Knownwell
    Needham, Massachusetts
    339-793-8998
  • Lucida Clinical Trials
    New Bedford, Massachusetts
    508-720-2015
Michigan2 sites
  • Headlands Research - Detroit
    Southfield, Michigan
  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
    Troy, Michigan
    248-312-0025
Missouri2 sites
  • StudyMetrix Research
    City of Saint Peters, Missouri
    636-387-5100
  • Clinvest Headlands Llc
    Springfield, Missouri
Nevada1 site
  • Las Vegas Medical Research
    Las Vegas, Nevada
    702-750-0000
New York4 sites
  • Dent Neurologic Institute
    Amherst, New York
  • Velocity Clinical Research, Syracuse
    East Syracuse, New York
  • North Suffolk Neurology
    Port Jefferson Station, New York
  • Rochester Clinical Research, LLC
    Rochester, New York
    585-288-0890
North Carolina4 sites
  • Medication Management
    Greensboro, North Carolina
    336-763-6968
  • Monroe Biomedical Research
    Monroe, North Carolina
    704-283-7359
  • Lucas Research, Inc
    Morehead City, North Carolina
    252-222-5700
  • Lucas Research, Inc.
    New Bern, North Carolina
    252-649-1944
Ohio1 site
  • CTI Clinical Research Center
    Cincinnati, Ohio
    513-721-3868
South Carolina1 site
  • Tribe Clinical Research, LLC
    Greenville, South Carolina
    864-334-0141
Tennessee1 site
  • Quality Medical Research
    Nashville, Tennessee
    615-835-4750
Texas7 sites
  • IMA Clinical Research Austin
    Austin, Texas
    512-649-0082
  • Velocity Clinical Research, Dallas
    Dallas, Texas
  • FutureSearch Trials of Dallas
    Dallas, Texas
    214-369-2600
  • PlanIt Research, PLLC
    Houston, Texas
    713-973-3415
  • Endeavor Clinical Trials
    San Antonio, Texas
    518-428-6859
  • Tekton Research - Fredericksburg Road
    San Antonio, Texas
  • Texas Valley Clinical Research
    Weslaco, Texas
    956-431-8090
Virginia1 site
  • Sovah Clinical Research-River District
    Danville, Virginia
    434-793-4711
Washington1 site
  • Central Washington Health Services Association d/b/a Confluence Health
    Wenatchee, Washington
    509-436-4050

Timeline

Started enrolling: November 17, 2023. Expected completion: February 2028. Last updated on ClinicalTrials.gov: August 6, 2026.

Official source

Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked August 21, 2026. Confirm the current status there before you contact a site:

View on ClinicalTrials.gov →

Back to the full directory → or take the matching quiz if you want clinical trials filtered to your conditions and location.

John Samaras, editor of GLP Chart
John Samaras, Founder and EditorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas.
About this site · LinkedIn · Contact
Why you can trust GLP Chart. Same scoring framework applied to every program. No paid placements. We never remove unfavorable information at an advertiser's request. Pricing is pulled from each program's public-facing page every Monday.